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- NCIT_C171370 IAO_0000115 "A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional chelator 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic acid (MeCOSar) and radiolabeled with the beta-emitting radioisotope copper Cu 67, with potential antineoplastic activity. Upon administration, copper Cu 67 Tyr3-octreotate binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. TATE is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NET and their metastases, while most other normal tissues express low levels of SSTRs." @default.
- NCIT_C171370 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171370 NCIT_A7 NCIT_C17922 @default.
- NCIT_C171370 NCIT_NHC0 "C171370" @default.
- NCIT_C171370 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C171370 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171370 NCIT_P107 "Copper Cu 67 Tyr3-octreotate" @default.
- NCIT_C171370 NCIT_P108 "Copper Cu 67 Tyr3-octreotate" @default.
- NCIT_C171370 NCIT_P208 "CL1405493" @default.
- NCIT_C171370 NCIT_P319 "Y6WKJ2X9X8" @default.
- NCIT_C171370 NCIT_P322 "CTRP" @default.
- NCIT_C171370 NCIT_P322 "FDA" @default.
- NCIT_C171370 NCIT_P322 "GDC" @default.
- NCIT_C171370 NCIT_P329 "801332" @default.
- NCIT_C171370 NCIT_P330 "801332" @default.
- NCIT_C171370 NCIT_P375 "Copper Cu 67 Tyr3-octreotate" @default.
- NCIT_C171370 NCIT_P399 "801332" @default.
- NCIT_C171370 normalizedInformationContent "100" @default.
- NCIT_C171370 referenceCount "1" @default.
- NCIT_C171370 hasExactSynonym "67Cu-SARTATE" @default.
- NCIT_C171370 hasExactSynonym "67Cu-labeled MeCOSar-Tyr3-octreotate" @default.
- NCIT_C171370 hasExactSynonym "Copper 67 SARTATE" @default.
- NCIT_C171370 hasExactSynonym "Copper Cu 67 TATE" @default.
- NCIT_C171370 hasExactSynonym "Copper Cu 67 Tyr3-octreotate" @default.
- NCIT_C171370 hasExactSynonym "Copper Cu 67-SARTATE" @default.
- NCIT_C171370 hasExactSynonym "Cu-67 SARTATE" @default.
- NCIT_C171370 hasExactSynonym "SARTATE CU-67" @default.
- NCIT_C171370 inSubset NCIT_C116977 @default.
- NCIT_C171370 inSubset NCIT_C116978 @default.
- NCIT_C171370 inSubset NCIT_C128784 @default.
- NCIT_C171370 inSubset NCIT_C157711 @default.
- NCIT_C171370 inSubset NCIT_C157712 @default.
- NCIT_C171370 inSubset NCIT_C176424 @default.
- NCIT_C171370 inSubset NCIT_C177537 @default.
- NCIT_C171370 inSubset NCIT_C63923 @default.
- NCIT_C171370 type Class @default.
- NCIT_C171370 isDefinedBy ncit.owl @default.
- NCIT_C171370 label "Copper Cu 67 Tyr3-octreotate" @default.
- NCIT_C171370 subClassOf NCIT_C129819 @default.
- NCIT_C171370 subClassOf NCIT_C1446 @default.
- NCIT_C171370 subClassOf NCIT_C171370 @default.
- NCIT_C171370 subClassOf NCIT_C1908 @default.
- NCIT_C171370 subClassOf NCIT_C1909 @default.
- NCIT_C171370 subClassOf NCIT_C2124 @default.
- NCIT_C171370 subClassOf NCIT_C274 @default.