Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C171377> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- NCIT_C171377 IAO_0000115 "A glyco-engineered heterodimeric bispecific monoclonal antibody, derived from trastuzumab and pertuzumab, directed against two distinct epitopes of the extracellular dimerization (ECD) domain of the tumor-associated antigen (TAA) human tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunomodulating and antineoplastic activities. Upon administration, recombinant humanized anti-HER-2 bispecific monoclonal antibody MBS301 simultaneously targets and binds to two separate, non-overlapping epitopes of HER-2. This prevents the activation of HER-2 signaling pathways. Also, by binding to HER-2, MBS301 induces an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells that overexpress HER-2. This results in tumor cell apoptosis and inhibits tumor cell proliferation of HER-2-overexpressing tumor cells. HER-2, overexpressed on a variety of tumor cell types, plays an important role in tumor cell proliferation, differentiation and survival." @default.
- NCIT_C171377 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171377 NCIT_A7 NCIT_C17319 @default.
- NCIT_C171377 NCIT_NHC0 "C171377" @default.
- NCIT_C171377 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C171377 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171377 NCIT_P108 "Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301" @default.
- NCIT_C171377 NCIT_P208 "CL1405488" @default.
- NCIT_C171377 NCIT_P322 "GDC" @default.
- NCIT_C171377 NCIT_P329 "801299" @default.
- NCIT_C171377 NCIT_P330 "801299" @default.
- NCIT_C171377 NCIT_P375 "Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301" @default.
- NCIT_C171377 NCIT_P399 "801299" @default.
- NCIT_C171377 NCIT_R124 NCIT_C17710 @default.
- NCIT_C171377 NCIT_R124 NCIT_C17828 @default.
- NCIT_C171377 NCIT_R124 NCIT_C18219 @default.
- NCIT_C171377 NCIT_R124 NCIT_C19986 @default.
- NCIT_C171377 NCIT_R124 NCIT_C40474 @default.
- NCIT_C171377 normalizedInformationContent "100" @default.
- NCIT_C171377 referenceCount "1" @default.
- NCIT_C171377 hasExactSynonym "Bispecific Anti-HER2 Antibody MBS301" @default.
- NCIT_C171377 hasExactSynonym "MBS 301" @default.
- NCIT_C171377 hasExactSynonym "MBS-301" @default.
- NCIT_C171377 hasExactSynonym "MBS301" @default.
- NCIT_C171377 hasExactSynonym "Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301" @default.
- NCIT_C171377 inSubset NCIT_C128784 @default.
- NCIT_C171377 inSubset NCIT_C157711 @default.
- NCIT_C171377 inSubset NCIT_C157712 @default.
- NCIT_C171377 inSubset NCIT_C176424 @default.
- NCIT_C171377 inSubset NCIT_C177537 @default.
- NCIT_C171377 type Class @default.
- NCIT_C171377 isDefinedBy ncit.owl @default.
- NCIT_C171377 label "Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301" @default.
- NCIT_C171377 subClassOf NCIT_C129821 @default.
- NCIT_C171377 subClassOf NCIT_C129822 @default.
- NCIT_C171377 subClassOf NCIT_C1454 @default.
- NCIT_C171377 subClassOf NCIT_C155711 @default.
- NCIT_C171377 subClassOf NCIT_C163758 @default.
- NCIT_C171377 subClassOf NCIT_C163760 @default.
- NCIT_C171377 subClassOf NCIT_C171377 @default.
- NCIT_C171377 subClassOf NCIT_C1908 @default.
- NCIT_C171377 subClassOf NCIT_C1909 @default.
- NCIT_C171377 subClassOf NCIT_C20401 @default.
- NCIT_C171377 subClassOf NCIT_C274 @default.
- NCIT_C171377 subClassOf NCIT_C28227 @default.
- NCIT_C171377 subClassOf NCIT_C307 @default.
- NCIT_C171377 subClassOf NCIT_C308 @default.