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- NCIT_C171540 IAO_0000115 "A recombinant, genetically modified, microRNA (miRNA)-attenuated oncolytic viral strain of the herpes simplex type 1 (HSV-1) virus, with potential oncolytic, immunostimulating and antineoplastic activities. In ONCR-177, a dual bidirectional promoter enables the expression of five different transgenes: the natural killer (NK) cell and T-cell activating cytokine interleuin-12 (IL-12), the chemokines C-C motif chemokine 4 (CCL4) and the extracellular domain of the Fms-related tyrosine kinase 3 ligand (FLT3LG), to allow for expansion and recruitment of classical dendritic cells (DCs), and antagonists to the immune checkpoints programmed cell death protein-1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to counter T cell exhaustion. Upon intra-tumoral administration, the oncolytic HSV-1 ONCR-177 specifically targets, infects and selectively replicates in tumor cells only while not infecting normal, healthy cells. This induces tumor cell lysis. The released virus particles then infect and replicate in neighboring tumor cells, thereby further killing tumor cells. The released tumor-associated antigens (TAAs) from the tumor cells activate the immune system to exert an anti-tumor immune response against the tumor cells, thereby further killing the tumor cells. In addition, the expressed transgenes that are released upon tumor cell lysis induce a systemic tumor-specific immune response and activate NKs, DCs and cytotoxic T-lymphocytes (CTLs) while inhibiting regulatory T-cells (Tregs). This further kills nearby non-infected tumor cells. In ONCR-177, the neurovirulence gene ICP34.5 allows for potent oncolysis, even in the presence of host cell antiviral responses. To ensure selective replication and oncolysis in cancer cells while attenuating replication in healthy tissue, tissue specific miRNA-binding cassettes (miR-T) are inserted into early genes essential for viral replication. In addition, UL37 mutation suppresses latent infection." @default.
- NCIT_C171540 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171540 NCIT_NHC0 "C171540" @default.
- NCIT_C171540 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171540 NCIT_P106 "Virus" @default.
- NCIT_C171540 NCIT_P107 "Oncolytic Herpes Simplex Virus-1 ONCR-177" @default.
- NCIT_C171540 NCIT_P108 "Oncolytic Herpes Simplex Virus-1 ONCR-177" @default.
- NCIT_C171540 NCIT_P208 "CL1405762" @default.
- NCIT_C171540 NCIT_P319 "83P3OQ67ZT" @default.
- NCIT_C171540 NCIT_P322 "CTRP" @default.
- NCIT_C171540 NCIT_P322 "FDA" @default.
- NCIT_C171540 NCIT_P322 "GDC" @default.
- NCIT_C171540 NCIT_P329 "802000" @default.
- NCIT_C171540 NCIT_P330 "802000" @default.
- NCIT_C171540 NCIT_P375 "Oncolytic Herpes Simplex Virus-1 ONCR-177" @default.
- NCIT_C171540 NCIT_P399 "802000" @default.
- NCIT_C171540 normalizedInformationContent "100" @default.
- NCIT_C171540 referenceCount "1" @default.
- NCIT_C171540 hasExactSynonym "ONCR 177" @default.
- NCIT_C171540 hasExactSynonym "ONCR-177" @default.
- NCIT_C171540 hasExactSynonym "ONCR177" @default.
- NCIT_C171540 hasExactSynonym "Oncolytic HSV-1 ONCR-177" @default.
- NCIT_C171540 hasExactSynonym "Oncolytic Herpes Simplex Virus-1 ONCR-177" @default.
- NCIT_C171540 hasExactSynonym "oHSV-1 ONCR-177" @default.
- NCIT_C171540 inSubset NCIT_C116977 @default.
- NCIT_C171540 inSubset NCIT_C116978 @default.
- NCIT_C171540 inSubset NCIT_C128784 @default.
- NCIT_C171540 inSubset NCIT_C157711 @default.
- NCIT_C171540 inSubset NCIT_C157712 @default.
- NCIT_C171540 inSubset NCIT_C176424 @default.
- NCIT_C171540 inSubset NCIT_C177537 @default.
- NCIT_C171540 inSubset NCIT_C63923 @default.
- NCIT_C171540 type Class @default.
- NCIT_C171540 isDefinedBy ncit.owl @default.
- NCIT_C171540 label "Oncolytic Herpes Simplex Virus-1 ONCR-177" @default.
- NCIT_C171540 subClassOf NCIT_C129821 @default.
- NCIT_C171540 subClassOf NCIT_C171540 @default.
- NCIT_C171540 subClassOf NCIT_C1908 @default.
- NCIT_C171540 subClassOf NCIT_C1909 @default.
- NCIT_C171540 subClassOf NCIT_C274 @default.
- NCIT_C171540 subClassOf NCIT_C307 @default.
- NCIT_C171540 subClassOf NCIT_C717 @default.