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- NCIT_C171541 IAO_0000115 "A humanized agonistic monoclonal antibody targeting the costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, exlinkibart targets and binds to CD137, thereby activating CD137 expressed on avariety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes a CTL-mediated anti-tumor immune response as well as induces NK-mediated tumor cell killing and suppresses the immunosuppressive activity of T-regulatory cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C171541 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171541 NCIT_A7 NCIT_C105113 @default.
- NCIT_C171541 NCIT_NHC0 "C171541" @default.
- NCIT_C171541 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C171541 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C171541 NCIT_P107 "Exlinkibart" @default.
- NCIT_C171541 NCIT_P108 "Exlinkibart" @default.
- NCIT_C171541 NCIT_P208 "CL1405761" @default.
- NCIT_C171541 NCIT_P210 "2642171-64-8" @default.
- NCIT_C171541 NCIT_P319 "23C7TO9S06" @default.
- NCIT_C171541 NCIT_P322 "CTRP" @default.
- NCIT_C171541 NCIT_P322 "FDA" @default.
- NCIT_C171541 NCIT_P322 "GDC" @default.
- NCIT_C171541 NCIT_P329 "801858" @default.
- NCIT_C171541 NCIT_P330 "801858" @default.
- NCIT_C171541 NCIT_P375 "Anti-CD137 Agonistic Monoclonal Antibody LVGN6051" @default.
- NCIT_C171541 NCIT_P399 "801858" @default.
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- NCIT_C171541 NCIT_R72 NCIT_C39567 @default.
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- NCIT_C171541 normalizedInformationContent "100" @default.
- NCIT_C171541 referenceCount "1" @default.
- NCIT_C171541 hasExactSynonym "Anti-4-1BB Agonistic Monoclonal Antibody LVGN6051" @default.
- NCIT_C171541 hasExactSynonym "Anti-CD137 Agonist Monoclonal Antibody LVGN6051" @default.
- NCIT_C171541 hasExactSynonym "Anti-CD137 Agonistic Monoclonal Antibody LVGN6051" @default.
- NCIT_C171541 hasExactSynonym "Anti-CD137 Monoclonal Antibody LVGN6051" @default.
- NCIT_C171541 hasExactSynonym "EXLINKIBART" @default.
- NCIT_C171541 hasExactSynonym "Exlinkibart" @default.
- NCIT_C171541 hasExactSynonym "LVGN 6051" @default.
- NCIT_C171541 hasExactSynonym "LVGN-6051" @default.
- NCIT_C171541 hasExactSynonym "LVGN6051" @default.
- NCIT_C171541 inSubset NCIT_C116977 @default.
- NCIT_C171541 inSubset NCIT_C116978 @default.
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- NCIT_C171541 inSubset NCIT_C177537 @default.
- NCIT_C171541 inSubset NCIT_C63923 @default.
- NCIT_C171541 type Class @default.
- NCIT_C171541 isDefinedBy ncit.owl @default.
- NCIT_C171541 label "Exlinkibart" @default.
- NCIT_C171541 subClassOf B0883eb74c29663857797b4ac7130e6dd @default.
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- NCIT_C171541 subClassOf NCIT_C192997 @default.
- NCIT_C171541 subClassOf NCIT_C20401 @default.
- NCIT_C171541 subClassOf NCIT_C274 @default.
- NCIT_C171541 subClassOf NCIT_C307 @default.
- NCIT_C171541 subClassOf NCIT_C308 @default.