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- NCIT_C171722 IAO_0000115 "The hydrochloride salt form of asciminib, an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both wild-type Bcr-Abl and certain mutation forms, including the T315I mutation. This binding results in the inhibition of Bcr-Abl1-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph+) hematological malignancies. The Bcr-Abl1 fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that contain the Philadelphia chromosome." @default.
- NCIT_C171722 NCIT_A6 NCIT_C114494 @default.
- NCIT_C171722 NCIT_NHC0 "C171722" @default.
- NCIT_C171722 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171722 NCIT_P108 "Asciminib Hydrochloride" @default.
- NCIT_C171722 NCIT_P208 "CL1405685" @default.
- NCIT_C171722 NCIT_P210 "2119669-71-3" @default.
- NCIT_C171722 NCIT_P302 "patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP" @default.
- NCIT_C171722 NCIT_P319 "C5U34S9XFV" @default.
- NCIT_C171722 NCIT_P322 "FDA" @default.
- NCIT_C171722 NCIT_P399 "758893" @default.
- NCIT_C171722 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C171722 referenceCount "2" @default.
- NCIT_C171722 hasExactSynonym "ABL001-AAA" @default.
- NCIT_C171722 hasExactSynonym "ASCIMINIB HYDROCHLORIDE" @default.
- NCIT_C171722 hasExactSynonym "Asciminib Hydrochloride" @default.
- NCIT_C171722 hasExactSynonym "N-[4-(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-3-yl)pyridine-3-carboxamidehydrogen Chloride (1/1)" @default.
- NCIT_C171722 hasExactSynonym "Scemblix" @default.
- NCIT_C171722 inSubset NCIT_C128784 @default.
- NCIT_C171722 inSubset NCIT_C176424 @default.
- NCIT_C171722 inSubset NCIT_C63923 @default.
- NCIT_C171722 type Class @default.
- NCIT_C171722 isDefinedBy ncit.owl @default.
- NCIT_C171722 label "Asciminib Hydrochloride" @default.
- NCIT_C171722 subClassOf NCIT_C129824 @default.
- NCIT_C171722 subClassOf NCIT_C129825 @default.
- NCIT_C171722 subClassOf NCIT_C171722 @default.
- NCIT_C171722 subClassOf NCIT_C1908 @default.
- NCIT_C171722 subClassOf NCIT_C1909 @default.
- NCIT_C171722 subClassOf NCIT_C2189 @default.
- NCIT_C171722 subClassOf NCIT_C274 @default.
- NCIT_C171722 subClassOf NCIT_C471 @default.