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- NCIT_C171840 IAO_0000115 "A bispecific humanized monoclonal antibody against human CD3, a T-cell surface antigen, and human G-protein coupled receptor family C group 5 member D (GPRC5D), a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, talquetamab binds to both CD3 on T-cells and GPRC5D expressed on certain tumor cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against GPRC5D-expressing tumor cells. GPRC5D is overexpressed on certain tumors, such as multiple myeloma, while minimally expressed on normal, healthy cells, and plays a key role in tumor cell proliferation." @default.
- NCIT_C171840 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171840 NCIT_A7 NCIT_C147936 @default.
- NCIT_C171840 NCIT_NHC0 "C171840" @default.
- NCIT_C171840 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C171840 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171840 NCIT_P107 "Talquetamab" @default.
- NCIT_C171840 NCIT_P108 "Talquetamab" @default.
- NCIT_C171840 NCIT_P208 "CL545429" @default.
- NCIT_C171840 NCIT_P210 "2226212-40-2" @default.
- NCIT_C171840 NCIT_P319 "4W3KFI3TN3" @default.
- NCIT_C171840 NCIT_P322 "CTRP" @default.
- NCIT_C171840 NCIT_P322 "FDA" @default.
- NCIT_C171840 NCIT_P322 "GDC" @default.
- NCIT_C171840 NCIT_P329 "792477" @default.
- NCIT_C171840 NCIT_P330 "792477" @default.
- NCIT_C171840 NCIT_P375 "Anti-CD3/Anti-GPRC5D Bispecific Monoclonal Antibody JNJ-64407564" @default.
- NCIT_C171840 NCIT_P399 "792477" @default.
- NCIT_C171840 NCIT_R124 NCIT_C17710 @default.
- NCIT_C171840 NCIT_R124 NCIT_C17828 @default.
- NCIT_C171840 NCIT_R124 NCIT_C18219 @default.
- NCIT_C171840 NCIT_R124 NCIT_C19986 @default.
- NCIT_C171840 NCIT_R124 NCIT_C40474 @default.
- NCIT_C171840 normalizedInformationContent "100" @default.
- NCIT_C171840 referenceCount "1" @default.
- NCIT_C171840 hasExactSynonym "Anti-CD3/Anti-GPRC5D Bispecific Monoclonal Antibody JNJ-64407564" @default.
- NCIT_C171840 hasExactSynonym "GPRC5D x CD3 Bispecific Antibody JNJ-64407564" @default.
- NCIT_C171840 hasExactSynonym "GPRC5D x CD3 DuoBody Antibody JNJ-64407564" @default.
- NCIT_C171840 hasExactSynonym "GPRC5D/CD3 DuoBody Antibody JNJ-64407564" @default.
- NCIT_C171840 hasExactSynonym "Humanized GPRC5D x CD3 DuoBody Antibody JNJ-64407564" @default.
- NCIT_C171840 hasExactSynonym "JNJ 64407564" @default.
- NCIT_C171840 hasExactSynonym "JNJ-64407564" @default.
- NCIT_C171840 hasExactSynonym "JNJ64407564" @default.
- NCIT_C171840 hasExactSynonym "TALQUETAMAB" @default.
- NCIT_C171840 hasExactSynonym "Talquetamab" @default.
- NCIT_C171840 inSubset NCIT_C116977 @default.
- NCIT_C171840 inSubset NCIT_C116978 @default.
- NCIT_C171840 inSubset NCIT_C128784 @default.
- NCIT_C171840 inSubset NCIT_C157711 @default.
- NCIT_C171840 inSubset NCIT_C157712 @default.
- NCIT_C171840 inSubset NCIT_C176424 @default.
- NCIT_C171840 inSubset NCIT_C177537 @default.
- NCIT_C171840 inSubset NCIT_C63923 @default.
- NCIT_C171840 type Class @default.
- NCIT_C171840 isDefinedBy ncit.owl @default.
- NCIT_C171840 label "Talquetamab" @default.
- NCIT_C171840 subClassOf NCIT_C112883 @default.
- NCIT_C171840 subClassOf NCIT_C129821 @default.
- NCIT_C171840 subClassOf NCIT_C129822 @default.
- NCIT_C171840 subClassOf NCIT_C1454 @default.
- NCIT_C171840 subClassOf NCIT_C171840 @default.
- NCIT_C171840 subClassOf NCIT_C1908 @default.
- NCIT_C171840 subClassOf NCIT_C1909 @default.
- NCIT_C171840 subClassOf NCIT_C201282 @default.
- NCIT_C171840 subClassOf NCIT_C20401 @default.
- NCIT_C171840 subClassOf NCIT_C274 @default.
- NCIT_C171840 subClassOf NCIT_C28227 @default.
- NCIT_C171840 subClassOf NCIT_C307 @default.
- NCIT_C171840 subClassOf NCIT_C308 @default.