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- NCIT_C171871 IAO_0000115 "An orally available inhibitor of the integral membrane protein gamma-secretase (GS), with potential antineoplastic activity. Upon administration, crenigacestat binds to the GS protease complex, thereby blocking the proteolytic cleavage and release of the Notch intracellular domain (NICD), which would normally follow ligand binding to the extracellular domain of the Notch receptor. This prevents both the subsequent translocation of NICD to the nucleus to form a transcription factor complex and the expression of Notch-regulated genes. This results in the induction of apoptosis and the inhibition of growth in tumor cells that overexpress Notch. Overexpression of the Notch signaling pathway plays an important role in tumor cell proliferation and survival." @default.
- NCIT_C171871 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171871 NCIT_A7 NCIT_C95114 @default.
- NCIT_C171871 NCIT_NHC0 "C171871" @default.
- NCIT_C171871 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171871 NCIT_P107 "Crenigacestat" @default.
- NCIT_C171871 NCIT_P108 "Crenigacestat" @default.
- NCIT_C171871 NCIT_P208 "CL1406068" @default.
- NCIT_C171871 NCIT_P210 "1421438-81-4" @default.
- NCIT_C171871 NCIT_P319 "923X28214S" @default.
- NCIT_C171871 NCIT_P322 "CTRP" @default.
- NCIT_C171871 NCIT_P322 "FDA" @default.
- NCIT_C171871 NCIT_P322 "GDC" @default.
- NCIT_C171871 NCIT_P375 "Gamma-Secretase Inhibitor LY3039478" @default.
- NCIT_C171871 NCIT_P399 "741069" @default.
- NCIT_C171871 normalizedInformationContent "100" @default.
- NCIT_C171871 referenceCount "1" @default.
- NCIT_C171871 hasExactSynonym "4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide" @default.
- NCIT_C171871 hasExactSynonym "BMS-986405" @default.
- NCIT_C171871 hasExactSynonym "CRENIGACESTAT" @default.
- NCIT_C171871 hasExactSynonym "Crenigacestat" @default.
- NCIT_C171871 hasExactSynonym "Gamma-Secretase Inhibitor LY3039478" @default.
- NCIT_C171871 hasExactSynonym "JSMD194" @default.
- NCIT_C171871 hasExactSynonym "LY 3039478" @default.
- NCIT_C171871 hasExactSynonym "LY-3039478" @default.
- NCIT_C171871 hasExactSynonym "LY3039478" @default.
- NCIT_C171871 inSubset NCIT_C116977 @default.
- NCIT_C171871 inSubset NCIT_C116978 @default.
- NCIT_C171871 inSubset NCIT_C128784 @default.
- NCIT_C171871 inSubset NCIT_C157711 @default.
- NCIT_C171871 inSubset NCIT_C157712 @default.
- NCIT_C171871 inSubset NCIT_C176424 @default.
- NCIT_C171871 inSubset NCIT_C177537 @default.
- NCIT_C171871 inSubset NCIT_C63923 @default.
- NCIT_C171871 type Class @default.
- NCIT_C171871 isDefinedBy ncit.owl @default.
- NCIT_C171871 label "Crenigacestat" @default.
- NCIT_C171871 subClassOf NCIT_C171871 @default.
- NCIT_C171871 subClassOf NCIT_C1908 @default.
- NCIT_C171871 subClassOf NCIT_C1909 @default.
- NCIT_C171871 subClassOf NCIT_C200529 @default.
- NCIT_C171871 subClassOf NCIT_C471 @default.
- NCIT_C171871 subClassOf NCIT_C783 @default.