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- NCIT_C171872 IAO_0000115 "An orally bioavailable, peptidomimetic inhibitor of hepatitis C virus (HCV) NS3/4A protease, with antiviral activity against HCV and potential antiviral activity against SARS-CoV-2. Upon oral administration, danoprevir binds to and blocks the activity of HCV NS3/4A protease. This prevents the cleavage and processing of HCV viral proteins leading to the inhibition of HCV replication. Danoprevir may also bind to and block of the activity of SARS-CoV-2 protease. This prevents the cleavage and processing of SARS-CoV-2 viral proteins leading to the inhibition of SARS-CoV-2 replication. NS3/4A, a chymotrypsin-like serine protease, is responsible for cleavage at four sites of the HCV polyprotein to form the viral proteins required for HCV replication. It plays a key role in the HCV viral replication process. HCV infection is associated with the development of hepatocellular carcinoma (HCC). A chymotrypsin-like protease is responsible for cleavage of the SARS-CoV-2 viral polyprotein to form the RNA replicase-transcriptase complex, which plays a key role in the SARS-CoV-2 viral transcription and replication process." @default.
- NCIT_C171872 NCIT_NHC0 "C171872" @default.
- NCIT_C171872 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171872 NCIT_P108 "Danoprevir" @default.
- NCIT_C171872 NCIT_P208 "CL1406067" @default.
- NCIT_C171872 NCIT_P210 "850876-88-9" @default.
- NCIT_C171872 NCIT_P319 "911Z9PCQ5F" @default.
- NCIT_C171872 NCIT_P322 "FDA" @default.
- NCIT_C171872 normalizedInformationContent "100" @default.
- NCIT_C171872 referenceCount "1" @default.
- NCIT_C171872 hasExactSynonym "DANOPREVIR" @default.
- NCIT_C171872 hasExactSynonym "Danoprevir" @default.
- NCIT_C171872 hasExactSynonym "ITMN 191" @default.
- NCIT_C171872 hasExactSynonym "ITMN-191" @default.
- NCIT_C171872 hasExactSynonym "ITMN191" @default.
- NCIT_C171872 hasExactSynonym "RG 7227" @default.
- NCIT_C171872 hasExactSynonym "RG-7227" @default.
- NCIT_C171872 hasExactSynonym "RG7227" @default.
- NCIT_C171872 inSubset NCIT_C173381 @default.
- NCIT_C171872 inSubset NCIT_C173383 @default.
- NCIT_C171872 inSubset NCIT_C63923 @default.
- NCIT_C171872 type Class @default.
- NCIT_C171872 isDefinedBy ncit.owl @default.
- NCIT_C171872 label "Danoprevir" @default.
- NCIT_C171872 subClassOf NCIT_C171872 @default.
- NCIT_C171872 subClassOf NCIT_C1908 @default.
- NCIT_C171872 subClassOf NCIT_C1909 @default.
- NCIT_C171872 subClassOf NCIT_C471 @default.
- NCIT_C171872 subClassOf NCIT_C783 @default.