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- NCIT_C171937 IAO_0000115 "An engineered fragment crystallizable (Fc) domain bispecific human immunoglobulin G1 (IgG1) monoclonal antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, volrustomig targets and binds to both PD-1 and CTLA4 expressed on tumor-infiltrating T lymphocytes (TILs), and inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. In addition, volrustomig is internalized and is able to degrade PD-1. This restores immune function and activates a sustained cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA4 are selectively expressed on TILs in the tumor microenvironment (TME) and negatively regulate the activation and effector functions of T-cells. They play key roles in the downregulation of the immune system and tumor evasion from host immunity. Dual checkpoint blockade of PD1 and CTLA4 with volrustomig may enhance T-cell activation and proliferation more than the blockade of either immune checkpoint receptor alone. It may also decrease toxicity by avoiding the binding to CTLA-4-expressing T-cells that are devoid of PD-1. The engineered Fc domain may reduce Fc effector function." @default.
- NCIT_C171937 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171937 NCIT_A7 NCIT_C17489 @default.
- NCIT_C171937 NCIT_A7 NCIT_C94697 @default.
- NCIT_C171937 NCIT_NHC0 "C171937" @default.
- NCIT_C171937 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171937 NCIT_P107 "Volrustomig" @default.
- NCIT_C171937 NCIT_P108 "Volrustomig" @default.
- NCIT_C171937 NCIT_P208 "CL1405903" @default.
- NCIT_C171937 NCIT_P210 "2407760-40-9" @default.
- NCIT_C171937 NCIT_P319 "K96EGJ218N" @default.
- NCIT_C171937 NCIT_P322 "CTRP" @default.
- NCIT_C171937 NCIT_P322 "FDA" @default.
- NCIT_C171937 NCIT_P322 "GDC" @default.
- NCIT_C171937 NCIT_P329 "802004" @default.
- NCIT_C171937 NCIT_P330 "802004" @default.
- NCIT_C171937 NCIT_P375 "Anti-PD-1/CTLA-4 Bispecific Antibody MEDI5752" @default.
- NCIT_C171937 NCIT_P399 "802004" @default.
- NCIT_C171937 NCIT_R124 NCIT_C17710 @default.
- NCIT_C171937 NCIT_R124 NCIT_C17828 @default.
- NCIT_C171937 NCIT_R124 NCIT_C18219 @default.
- NCIT_C171937 NCIT_R124 NCIT_C19986 @default.
- NCIT_C171937 NCIT_R124 NCIT_C40474 @default.
- NCIT_C171937 normalizedInformationContent "100" @default.
- NCIT_C171937 referenceCount "1" @default.
- NCIT_C171937 hasExactSynonym "Anti-PD-1 x CTLA-4 Bispecific Antibody MEDI5752" @default.
- NCIT_C171937 hasExactSynonym "Anti-PD-1/Anti-CTLA-4 Bispecific Antibody MEDI5752" @default.
- NCIT_C171937 hasExactSynonym "Anti-PD-1/CTLA-4 Bispecific Antibody MEDI5752" @default.
- NCIT_C171937 hasExactSynonym "MEDI 5752" @default.
- NCIT_C171937 hasExactSynonym "MEDI-5752" @default.
- NCIT_C171937 hasExactSynonym "MEDI5752" @default.
- NCIT_C171937 hasExactSynonym "VOLRUSTOMIG" @default.
- NCIT_C171937 hasExactSynonym "Volrustomig" @default.
- NCIT_C171937 inSubset NCIT_C116977 @default.
- NCIT_C171937 inSubset NCIT_C116978 @default.
- NCIT_C171937 inSubset NCIT_C128784 @default.
- NCIT_C171937 inSubset NCIT_C157711 @default.
- NCIT_C171937 inSubset NCIT_C157712 @default.
- NCIT_C171937 inSubset NCIT_C176424 @default.
- NCIT_C171937 inSubset NCIT_C177537 @default.
- NCIT_C171937 inSubset NCIT_C63923 @default.
- NCIT_C171937 type Class @default.
- NCIT_C171937 isDefinedBy ncit.owl @default.
- NCIT_C171937 label "Volrustomig" @default.
- NCIT_C171937 subClassOf NCIT_C129821 @default.
- NCIT_C171937 subClassOf NCIT_C129822 @default.
- NCIT_C171937 subClassOf NCIT_C141144 @default.
- NCIT_C171937 subClassOf NCIT_C143250 @default.
- NCIT_C171937 subClassOf NCIT_C1454 @default.
- NCIT_C171937 subClassOf NCIT_C171937 @default.
- NCIT_C171937 subClassOf NCIT_C1908 @default.
- NCIT_C171937 subClassOf NCIT_C1909 @default.
- NCIT_C171937 subClassOf NCIT_C20401 @default.
- NCIT_C171937 subClassOf NCIT_C274 @default.
- NCIT_C171937 subClassOf NCIT_C28227 @default.
- NCIT_C171937 subClassOf NCIT_C307 @default.
- NCIT_C171937 subClassOf NCIT_C308 @default.