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- NCIT_C172104 IAO_0000115 "An orally bioavailable steroidal cortexolone derivative and antagonist of the androgen receptor (AR) and glucocorticoid receptor (GR), with potential antineoplastic activity. Upon oral administration, AR/GR antagonist CB-03-10 specifically binds to AR and GR, inhibits AR and GR activation, and prevents AR- and GR-mediated signaling. This leads to an induction of both extrinsic and intrinsic apoptotic pathways and inhibits cell growth in AR- and GR-overexpressing tumor cells. AR and GR are overexpressed in certain types of cancer cells and are involved in proliferation, survival and chemoresistance of tumor cells." @default.
- NCIT_C172104 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172104 NCIT_NHC0 "C172104" @default.
- NCIT_C172104 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172104 NCIT_P107 "Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10" @default.
- NCIT_C172104 NCIT_P108 "Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10" @default.
- NCIT_C172104 NCIT_P208 "CL1406219" @default.
- NCIT_C172104 NCIT_P322 "CTRP" @default.
- NCIT_C172104 NCIT_P322 "GDC" @default.
- NCIT_C172104 NCIT_P329 "801352" @default.
- NCIT_C172104 NCIT_P330 "801352" @default.
- NCIT_C172104 NCIT_P375 "Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10" @default.
- NCIT_C172104 NCIT_P399 "801352" @default.
- NCIT_C172104 normalizedInformationContent "100" @default.
- NCIT_C172104 referenceCount "1" @default.
- NCIT_C172104 hasExactSynonym "AR/GR Antagonist CB-03-10" @default.
- NCIT_C172104 hasExactSynonym "Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10" @default.
- NCIT_C172104 hasExactSynonym "CB 03 10" @default.
- NCIT_C172104 hasExactSynonym "CB-03-10" @default.
- NCIT_C172104 hasExactSynonym "CB0310" @default.
- NCIT_C172104 hasExactSynonym "Cortexolone 17alpha-Valerate-21-propionate" @default.
- NCIT_C172104 inSubset NCIT_C116977 @default.
- NCIT_C172104 inSubset NCIT_C116978 @default.
- NCIT_C172104 inSubset NCIT_C128784 @default.
- NCIT_C172104 inSubset NCIT_C157711 @default.
- NCIT_C172104 inSubset NCIT_C157712 @default.
- NCIT_C172104 inSubset NCIT_C176424 @default.
- NCIT_C172104 inSubset NCIT_C177537 @default.
- NCIT_C172104 type Class @default.
- NCIT_C172104 isDefinedBy ncit.owl @default.
- NCIT_C172104 label "Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10" @default.
- NCIT_C172104 subClassOf NCIT_C146993 @default.
- NCIT_C172104 subClassOf NCIT_C147908 @default.
- NCIT_C172104 subClassOf NCIT_C163758 @default.
- NCIT_C172104 subClassOf NCIT_C172104 @default.
- NCIT_C172104 subClassOf NCIT_C1908 @default.
- NCIT_C172104 subClassOf NCIT_C1909 @default.
- NCIT_C172104 subClassOf NCIT_C242 @default.
- NCIT_C172104 subClassOf NCIT_C274 @default.
- NCIT_C172104 subClassOf NCIT_C547 @default.