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- NCIT_C172109 IAO_0000115 "An orally bioavailable immune checkpoint inhibitor and antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration, inupadenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. This prevents tumor-released adenosine from interacting with the A2A receptors, thereby blocking the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression." @default.
- NCIT_C172109 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172109 NCIT_A7 NCIT_C38612 @default.
- NCIT_C172109 NCIT_NHC0 "C172109" @default.
- NCIT_C172109 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172109 NCIT_P107 "Inupadenant" @default.
- NCIT_C172109 NCIT_P108 "Inupadenant" @default.
- NCIT_C172109 NCIT_P208 "CL1413218" @default.
- NCIT_C172109 NCIT_P210 "2246607-08-7" @default.
- NCIT_C172109 NCIT_P319 "HQ700V0X06" @default.
- NCIT_C172109 NCIT_P322 "CTRP" @default.
- NCIT_C172109 NCIT_P322 "FDA" @default.
- NCIT_C172109 NCIT_P322 "GDC" @default.
- NCIT_C172109 NCIT_P329 "801361" @default.
- NCIT_C172109 NCIT_P330 "801361" @default.
- NCIT_C172109 NCIT_P375 "A2A Receptor Antagonist EOS100850" @default.
- NCIT_C172109 NCIT_P399 "801361" @default.
- NCIT_C172109 normalizedInformationContent "100" @default.
- NCIT_C172109 referenceCount "1" @default.
- NCIT_C172109 hasExactSynonym "A2A Receptor Antagonist EOS100850" @default.
- NCIT_C172109 hasExactSynonym "EOS 100850" @default.
- NCIT_C172109 hasExactSynonym "EOS-100850" @default.
- NCIT_C172109 hasExactSynonym "EOS100850" @default.
- NCIT_C172109 hasExactSynonym "INUPADENANT" @default.
- NCIT_C172109 hasExactSynonym "Inupadenant" @default.
- NCIT_C172109 inSubset NCIT_C116977 @default.
- NCIT_C172109 inSubset NCIT_C116978 @default.
- NCIT_C172109 inSubset NCIT_C128784 @default.
- NCIT_C172109 inSubset NCIT_C157711 @default.
- NCIT_C172109 inSubset NCIT_C157712 @default.
- NCIT_C172109 inSubset NCIT_C176424 @default.
- NCIT_C172109 inSubset NCIT_C177537 @default.
- NCIT_C172109 inSubset NCIT_C63923 @default.
- NCIT_C172109 type Class @default.
- NCIT_C172109 isDefinedBy ncit.owl @default.
- NCIT_C172109 label "Inupadenant" @default.
- NCIT_C172109 subClassOf NCIT_C172109 @default.
- NCIT_C172109 subClassOf NCIT_C1908 @default.
- NCIT_C172109 subClassOf NCIT_C1909 @default.
- NCIT_C172109 subClassOf NCIT_C2139 @default.
- NCIT_C172109 subClassOf NCIT_C308 @default.