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- NCIT_C172110 IAO_0000115 "A dietary powder supplement consisting of a mixture of various, as of yet not fully elucidated, berries, with potential antineoplastic and anti-angiogenic activities. As berries are rich in phytonutrients, such as anthocyanins, flavonols, ellagitannins, galltannins, proanthocyanidins, and phenolic acids, the antineoplastic effects of the powdered mixed berry extract supplement on cancer cells may be attributable to the phytonutrients' antioxidant and pro-apoptotic activities. Upon administration of the powdered mixed berry extract supplement, the phytochemicals in the berries may work together to reduce angiogenesis, tumor growth and tumor development. Specifically, various phytochemicals may inhibit the multidrug resistance protein-1 (MRP-1), which results in the accumulation of cellular oxidized glutathione (GSSG). Elevated intracellular levels of GSSG causes an increase in oxidative stress. This triggers the induction of oxidative stress-mediated apoptosis and may inhibit tumor and endothelial cell proliferation. MRP-1, overexpressed in many different types of cancer, plays a key role in the efflux of GSSG and thus the maintenance of oxidative homeostasis and survival in tumor cells." @default.
- NCIT_C172110 NCIT_NHC0 "C172110" @default.
- NCIT_C172110 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172110 NCIT_P108 "Powdered Mixed Berry Extract Supplement" @default.
- NCIT_C172110 NCIT_P208 "CL1406213" @default.
- NCIT_C172110 NCIT_P329 "801392" @default.
- NCIT_C172110 NCIT_P330 "801392" @default.
- NCIT_C172110 NCIT_P399 "801392" @default.
- NCIT_C172110 normalizedInformationContent "100" @default.
- NCIT_C172110 referenceCount "1" @default.
- NCIT_C172110 hasExactSynonym "PediaBerry" @default.
- NCIT_C172110 hasExactSynonym "Powdered Berry Extracts Blend" @default.
- NCIT_C172110 hasExactSynonym "Powdered Berry Extracts" @default.
- NCIT_C172110 hasExactSynonym "Powdered Mixed Berry Extract Supplement" @default.
- NCIT_C172110 hasExactSynonym "Powdered NBE" @default.
- NCIT_C172110 hasExactSynonym "Powdered Natural Berry Extracts" @default.
- NCIT_C172110 inSubset NCIT_C128784 @default.
- NCIT_C172110 inSubset NCIT_C176424 @default.
- NCIT_C172110 type Class @default.
- NCIT_C172110 isDefinedBy ncit.owl @default.
- NCIT_C172110 label "Powdered Mixed Berry Extract Supplement" @default.
- NCIT_C172110 subClassOf NCIT_C1505 @default.
- NCIT_C172110 subClassOf NCIT_C172110 @default.
- NCIT_C172110 subClassOf NCIT_C1908 @default.