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- NCIT_C172194 IAO_0000115 "A recombinant, Fc-silenced immunoglobulin G1 (IgG1) bispecific antibody targeting both the human programmed death-ligand 1 (PD-L1) and 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, acasunlimab simultaneously targets and binds to 4-1BB, which is expressed on a variety of leukocyte subsets including activated T-lymphocytes, and PD-L1 expressed on tumor cells. Through 4-1BB binding, acasunlimab acts as a conditional 4-1BB agonist, resulting in T-cell co-stimulation and enhances T-lymphocyte-mediated anti-tumor activity. At the same time, acasunlimab prevents PD-L1 from binding to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C172194 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172194 NCIT_A7 NCIT_C96024 @default.
- NCIT_C172194 NCIT_NHC0 "C172194" @default.
- NCIT_C172194 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C172194 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C172194 NCIT_P107 "Acasunlimab" @default.
- NCIT_C172194 NCIT_P108 "Acasunlimab" @default.
- NCIT_C172194 NCIT_P208 "CL1406283" @default.
- NCIT_C172194 NCIT_P210 "2253937-12-9" @default.
- NCIT_C172194 NCIT_P319 "H52ITZ9X9D" @default.
- NCIT_C172194 NCIT_P322 "CTRP" @default.
- NCIT_C172194 NCIT_P322 "FDA" @default.
- NCIT_C172194 NCIT_P322 "GDC" @default.
- NCIT_C172194 NCIT_P329 "801584" @default.
- NCIT_C172194 NCIT_P330 "801584" @default.
- NCIT_C172194 NCIT_P375 "Anti-PD-L1/Anti-4-1BB Bispecific Monoclonal Antibody GEN1046" @default.
- NCIT_C172194 NCIT_P399 "801584" @default.
- NCIT_C172194 NCIT_R124 NCIT_C17710 @default.
- NCIT_C172194 NCIT_R124 NCIT_C17828 @default.
- NCIT_C172194 NCIT_R124 NCIT_C18219 @default.
- NCIT_C172194 NCIT_R124 NCIT_C19986 @default.
- NCIT_C172194 NCIT_R124 NCIT_C40474 @default.
- NCIT_C172194 normalizedInformationContent "100" @default.
- NCIT_C172194 referenceCount "1" @default.
- NCIT_C172194 hasExactSynonym "ACASUNLIMAB" @default.
- NCIT_C172194 hasExactSynonym "Acasunlimab" @default.
- NCIT_C172194 hasExactSynonym "Anti-PD-L1/Anti-4-1BB Bispecific Monoclonal Antibody GEN1046" @default.
- NCIT_C172194 hasExactSynonym "BNT 311" @default.
- NCIT_C172194 hasExactSynonym "DuoBody PD-L1 x 4-1BB GEN1046" @default.
- NCIT_C172194 hasExactSynonym "GEN 1046" @default.
- NCIT_C172194 hasExactSynonym "GEN-1046" @default.
- NCIT_C172194 hasExactSynonym "GEN1046" @default.
- NCIT_C172194 inSubset NCIT_C116977 @default.
- NCIT_C172194 inSubset NCIT_C116978 @default.
- NCIT_C172194 inSubset NCIT_C128784 @default.
- NCIT_C172194 inSubset NCIT_C157711 @default.
- NCIT_C172194 inSubset NCIT_C157712 @default.
- NCIT_C172194 inSubset NCIT_C176424 @default.
- NCIT_C172194 inSubset NCIT_C177537 @default.
- NCIT_C172194 inSubset NCIT_C63923 @default.
- NCIT_C172194 type Class @default.
- NCIT_C172194 isDefinedBy ncit.owl @default.
- NCIT_C172194 label "Acasunlimab" @default.
- NCIT_C172194 subClassOf NCIT_C128057 @default.
- NCIT_C172194 subClassOf NCIT_C129820 @default.
- NCIT_C172194 subClassOf NCIT_C141144 @default.
- NCIT_C172194 subClassOf NCIT_C143250 @default.
- NCIT_C172194 subClassOf NCIT_C1454 @default.
- NCIT_C172194 subClassOf NCIT_C155745 @default.
- NCIT_C172194 subClassOf NCIT_C156893 @default.
- NCIT_C172194 subClassOf NCIT_C163758 @default.
- NCIT_C172194 subClassOf NCIT_C172194 @default.
- NCIT_C172194 subClassOf NCIT_C1908 @default.
- NCIT_C172194 subClassOf NCIT_C1909 @default.
- NCIT_C172194 subClassOf NCIT_C191689 @default.
- NCIT_C172194 subClassOf NCIT_C192997 @default.
- NCIT_C172194 subClassOf NCIT_C20401 @default.
- NCIT_C172194 subClassOf NCIT_C274 @default.
- NCIT_C172194 subClassOf NCIT_C28227 @default.
- NCIT_C172194 subClassOf NCIT_C307 @default.
- NCIT_C172194 subClassOf NCIT_C308 @default.