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- NCIT_C172196 IAO_0000115 "A fixed dose combination of two monoclonal antibodies of which one is directed against the human negative immunoregulatory checkpoint receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and the other one is directed against the cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA-4/anti-PD-1 monoclonal antibody combination BCD-217 targets and binds to both PD-1 and CTLA-4 expressed on tumor-infiltrating lymphocytes (TILs) and inhibits the PD-1- and CTLA-4-mediated downregulation of T-cell activation and proliferation. This restores immune function and activates a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA-4 are selectively expressed on TILs in the tumor microenvironment (TME) and negatively regulate the activation and effector functions of T-cells. They play key roles in the downregulation of the immune system and tumor evasion from host immunity. Dual checkpoint blockade of PD-1 and CTLA-4 enhances T-cell activation and proliferation more than the blockade of either immune checkpoint receptor alone." @default.
- NCIT_C172196 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172196 NCIT_A7 NCIT_C17489 @default.
- NCIT_C172196 NCIT_NHC0 "C172196" @default.
- NCIT_C172196 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172196 NCIT_P108 "Anti-CTLA-4/Anti-PD-1 Monoclonal Antibody Combination BCD-217" @default.
- NCIT_C172196 NCIT_P208 "CL1406094" @default.
- NCIT_C172196 NCIT_P322 "GDC" @default.
- NCIT_C172196 NCIT_P329 "801536" @default.
- NCIT_C172196 NCIT_P330 "801536" @default.
- NCIT_C172196 NCIT_P375 "Anti-CTLA-4/Anti-PD-1 Monoclonal Antibody Combination BCD-217" @default.
- NCIT_C172196 NCIT_P399 "801536" @default.
- NCIT_C172196 NCIT_R124 NCIT_C17710 @default.
- NCIT_C172196 NCIT_R124 NCIT_C17828 @default.
- NCIT_C172196 NCIT_R124 NCIT_C18219 @default.
- NCIT_C172196 NCIT_R124 NCIT_C19986 @default.
- NCIT_C172196 NCIT_R124 NCIT_C40474 @default.
- NCIT_C172196 normalizedInformationContent "100" @default.
- NCIT_C172196 referenceCount "1" @default.
- NCIT_C172196 hasExactSynonym "Anti-CTLA-4/Anti-PD-1 Monoclonal Antibody Combination BCD-217" @default.
- NCIT_C172196 hasExactSynonym "Anti-CTLA-4/PD-1 Monoclonal Antibody Combination BCD-217" @default.
- NCIT_C172196 hasExactSynonym "Anti-CTLA4/Anti-PD1 Monoclonal Antibody Combination BCD-217" @default.
- NCIT_C172196 hasExactSynonym "BCD 217" @default.
- NCIT_C172196 hasExactSynonym "BCD-217" @default.
- NCIT_C172196 hasExactSynonym "BCD217" @default.
- NCIT_C172196 inSubset NCIT_C128784 @default.
- NCIT_C172196 inSubset NCIT_C157711 @default.
- NCIT_C172196 inSubset NCIT_C157712 @default.
- NCIT_C172196 inSubset NCIT_C176424 @default.
- NCIT_C172196 inSubset NCIT_C177537 @default.
- NCIT_C172196 type Class @default.
- NCIT_C172196 isDefinedBy ncit.owl @default.
- NCIT_C172196 label "Anti-CTLA-4/Anti-PD-1 Monoclonal Antibody Combination BCD-217" @default.
- NCIT_C172196 subClassOf NCIT_C124946 @default.
- NCIT_C172196 subClassOf NCIT_C128036 @default.
- NCIT_C172196 subClassOf NCIT_C128037 @default.
- NCIT_C172196 subClassOf NCIT_C129821 @default.
- NCIT_C172196 subClassOf NCIT_C129822 @default.
- NCIT_C172196 subClassOf NCIT_C141144 @default.
- NCIT_C172196 subClassOf NCIT_C143250 @default.
- NCIT_C172196 subClassOf NCIT_C1454 @default.
- NCIT_C172196 subClassOf NCIT_C163758 @default.
- NCIT_C172196 subClassOf NCIT_C172196 @default.
- NCIT_C172196 subClassOf NCIT_C1908 @default.
- NCIT_C172196 subClassOf NCIT_C1909 @default.
- NCIT_C172196 subClassOf NCIT_C191738 @default.
- NCIT_C172196 subClassOf NCIT_C20401 @default.
- NCIT_C172196 subClassOf NCIT_C274 @default.
- NCIT_C172196 subClassOf NCIT_C28227 @default.
- NCIT_C172196 subClassOf NCIT_C307 @default.
- NCIT_C172196 subClassOf NCIT_C308 @default.