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- NCIT_C172205 IAO_0000115 "A cancer vaccine consisting of a combination of two vaccines, a prime pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine and a boost HPV16 L2/E6/E7 fusion protein TA-CIN vaccine, with potential immunostimulating and antineoplastic activities. pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine is an antigen-specific DNA cancer vaccine consisting of the coding sequences of a signal peptide (pNGVL4a-Sig), a detox form of the human papillomavirus type 16 (HPV-16) antigen E7, and the heat shock protein 70 (HSP70). Upon administration, this prime vaccine may generate potent cytotoxic CD8(+) T-cell responses against E7-expressing tumor cells, resulting in tumor cell death. HPV16 L2/E6/E7 fusion protein TA-CIN vaccine is a recombinant human papillomavirus (HPV), genetically engineered fusion protein vaccine in which the three HPV16 viral proteins L2, E6 and E7 are fused together in a single tandem fusion protein (TA-CIN; HPV16 L2\E6\E7). Upon administration, this boost vaccine may stimulate the immune system to generate HPV16 E6\E7-specific CD4+ and CD8+ T-cell responses as well as the induction of L2-specific antibodies. In addition, this vaccine may prevent infection and the development of other HPV16-associated diseases. L2, a minor viral capsid protein, is able to induce a strong antibody response against certain HPV types." @default.
- NCIT_C172205 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172205 NCIT_NHC0 "C172205" @default.
- NCIT_C172205 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172205 NCIT_P108 "pNGVL4a-Sig/E7(detox)/HSP70 DNA and HPV16 L2/E6/E7 Fusion Protein TA-CIN Vaccine PVX-2" @default.
- NCIT_C172205 NCIT_P208 "CL1406087" @default.
- NCIT_C172205 NCIT_P322 "GDC" @default.
- NCIT_C172205 NCIT_P329 "801534" @default.
- NCIT_C172205 NCIT_P330 "801534" @default.
- NCIT_C172205 NCIT_P375 "pNGVL4a-Sig/E7(detox)/HSP70 DNA and HPV16 L2/E6/E7 Fusion Protein TA-CIN Vaccine PVX-2" @default.
- NCIT_C172205 NCIT_P399 "801534" @default.
- NCIT_C172205 normalizedInformationContent "100" @default.
- NCIT_C172205 referenceCount "1" @default.
- NCIT_C172205 hasExactSynonym "PVX 2" @default.
- NCIT_C172205 hasExactSynonym "PVX-2" @default.
- NCIT_C172205 hasExactSynonym "PVX2" @default.
- NCIT_C172205 hasExactSynonym "pNGVL4a-Sig/E7(detox)/HSP70 DNA and HPV16 L2/E6/E7 Fusion Protein TA-CIN Vaccine PVX-2" @default.
- NCIT_C172205 inSubset NCIT_C128784 @default.
- NCIT_C172205 inSubset NCIT_C157711 @default.
- NCIT_C172205 inSubset NCIT_C157712 @default.
- NCIT_C172205 inSubset NCIT_C176424 @default.
- NCIT_C172205 inSubset NCIT_C177537 @default.
- NCIT_C172205 type Class @default.
- NCIT_C172205 isDefinedBy ncit.owl @default.
- NCIT_C172205 label "pNGVL4a-Sig/E7(detox)/HSP70 DNA and HPV16 L2/E6/E7 Fusion Protein TA-CIN Vaccine PVX-2" @default.
- NCIT_C172205 subClassOf NCIT_C129820 @default.
- NCIT_C172205 subClassOf NCIT_C1663 @default.
- NCIT_C172205 subClassOf NCIT_C172205 @default.
- NCIT_C172205 subClassOf NCIT_C1908 @default.
- NCIT_C172205 subClassOf NCIT_C1909 @default.
- NCIT_C172205 subClassOf NCIT_C274 @default.
- NCIT_C172205 subClassOf NCIT_C307 @default.
- NCIT_C172205 subClassOf NCIT_C308 @default.
- NCIT_C172205 subClassOf NCIT_C39619 @default.
- NCIT_C172205 subClassOf NCIT_C923 @default.