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- NCIT_C172366 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically engineered to express a single-domain antibody that recognizes human CD19, fused to the CD3-epsilon T-cell receptor (TCR) subunit which, upon expression is incorporated into the endogenous TCR complex, with potential antineoplastic activity. Upon administration, the autologous anti-CD19 TCR fusion construct (TRuC) T-cells TC-110 specifically target and bind to CD19-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. Compared to chimeric antigen receptor (CAR) T-cells, TRuCs may be associated with less pro-inflammatory cytokine secretion and fewer adverse effects without compromising therapeutic efficacy." @default.
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- NCIT_C172366 NCIT_P107 "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110" @default.
- NCIT_C172366 NCIT_P108 "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110" @default.
- NCIT_C172366 NCIT_P208 "CL1406524" @default.
- NCIT_C172366 NCIT_P322 "CTRP" @default.
- NCIT_C172366 NCIT_P329 "802016" @default.
- NCIT_C172366 NCIT_P330 "802016" @default.
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- NCIT_C172366 hasExactSynonym "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110" @default.
- NCIT_C172366 hasExactSynonym "Autologous Anti-CD19 TRuC T-cells TC-110" @default.
- NCIT_C172366 hasExactSynonym "CD19-specific Epsilon-TRuC TC-110" @default.
- NCIT_C172366 hasExactSynonym "CD19-specific T Cell Receptor Fusion Construct T cell TC-110" @default.
- NCIT_C172366 hasExactSynonym "TC 110 T Cells" @default.
- NCIT_C172366 hasExactSynonym "TC 110" @default.
- NCIT_C172366 hasExactSynonym "TC-110 T Cells" @default.
- NCIT_C172366 hasExactSynonym "TC-110" @default.
- NCIT_C172366 hasExactSynonym "TC110 T Cells" @default.
- NCIT_C172366 hasExactSynonym "TC110" @default.
- NCIT_C172366 hasExactSynonym "TRuC T Cells TC-110" @default.
- NCIT_C172366 hasExactSynonym "TRuC-T Cell-targeting CD19 TC-110" @default.
- NCIT_C172366 inSubset NCIT_C116977 @default.
- NCIT_C172366 inSubset NCIT_C116978 @default.
- NCIT_C172366 inSubset NCIT_C128784 @default.
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- NCIT_C172366 type Class @default.
- NCIT_C172366 isDefinedBy ncit.owl @default.
- NCIT_C172366 label "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110" @default.
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- NCIT_C172366 subClassOf NCIT_C274 @default.
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- NCIT_C172366 subClassOf NCIT_C307 @default.
- NCIT_C172366 subClassOf NCIT_C308 @default.