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- NCIT_C172390 IAO_0000115 "An orally bioavailable, selective inhibitor of cyclin-dependent kinase 7 (CDK7), with potential antineoplastic activity. Upon oral administration, SY-5609 selectively targets, binds to and inhibits the activity of CDK7, thereby inhibiting CDK7-mediated signaling. Specifically, inhibition of CDK7 prevents phosphorylation of the carboxy-terminal domain (CTD) of RNA Polymerase II, thereby preventing transcription of important cancer-promoting genes. In addition, it prevents phosphorylation of the cell cycle kinases CDK1, 2, 4, and 6, thereby disrupting uncontrolled cell cycle progression. Altogether, this may induce apoptosis, cause cell cycle arrest, inhibit DNA damage repair and inhibit tumor cell proliferation in certain cancers that are dependent on CDK7-mediated transcriptional regulation and signaling. CDK7, a serine/threonine kinase, plays a role in controlling cell cycle progression, transcriptional regulation, and promotes the expression of key oncogenes such as c-Myc and beta-catenin, through the phosphorylation of RNA polymerase II." @default.
- NCIT_C172390 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172390 NCIT_A7 NCIT_C89769 @default.
- NCIT_C172390 NCIT_NHC0 "C172390" @default.
- NCIT_C172390 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172390 NCIT_P107 "CDK7 Inhibitor SY-5609" @default.
- NCIT_C172390 NCIT_P108 "CDK7 Inhibitor SY-5609" @default.
- NCIT_C172390 NCIT_P208 "CL1406516" @default.
- NCIT_C172390 NCIT_P322 "CTRP" @default.
- NCIT_C172390 NCIT_P322 "GDC" @default.
- NCIT_C172390 NCIT_P329 "802022" @default.
- NCIT_C172390 NCIT_P330 "802022" @default.
- NCIT_C172390 NCIT_P375 "CDK7 Inhibitor SY-5609" @default.
- NCIT_C172390 NCIT_P399 "802022" @default.
- NCIT_C172390 normalizedInformationContent "100" @default.
- NCIT_C172390 referenceCount "1" @default.
- NCIT_C172390 hasExactSynonym "CDK7 Inhibitor SY-5609" @default.
- NCIT_C172390 hasExactSynonym "Cyclin-dependent Kinase 7 Inhibitor SY-5609" @default.
- NCIT_C172390 hasExactSynonym "SY 5609" @default.
- NCIT_C172390 hasExactSynonym "SY-5609" @default.
- NCIT_C172390 hasExactSynonym "SY5609" @default.
- NCIT_C172390 inSubset NCIT_C116977 @default.
- NCIT_C172390 inSubset NCIT_C116978 @default.
- NCIT_C172390 inSubset NCIT_C128784 @default.
- NCIT_C172390 inSubset NCIT_C157711 @default.
- NCIT_C172390 inSubset NCIT_C157712 @default.
- NCIT_C172390 inSubset NCIT_C176424 @default.
- NCIT_C172390 inSubset NCIT_C177537 @default.
- NCIT_C172390 type Class @default.
- NCIT_C172390 isDefinedBy ncit.owl @default.
- NCIT_C172390 label "CDK7 Inhibitor SY-5609" @default.
- NCIT_C172390 subClassOf NCIT_C129824 @default.
- NCIT_C172390 subClassOf NCIT_C129825 @default.
- NCIT_C172390 subClassOf NCIT_C1404 @default.
- NCIT_C172390 subClassOf NCIT_C163758 @default.
- NCIT_C172390 subClassOf NCIT_C172390 @default.
- NCIT_C172390 subClassOf NCIT_C1908 @default.
- NCIT_C172390 subClassOf NCIT_C1909 @default.
- NCIT_C172390 subClassOf NCIT_C2185 @default.
- NCIT_C172390 subClassOf NCIT_C2189 @default.
- NCIT_C172390 subClassOf NCIT_C274 @default.
- NCIT_C172390 subClassOf NCIT_C471 @default.
- NCIT_C172390 subClassOf NCIT_C61074 @default.