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- NCIT_C172396 IAO_0000115 "A modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon administration, golcadomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, some of which are transcriptional repressors in T-cells. This leads to modulation of the immune system, including activation of T-lymphocytes, and downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins." @default.
- NCIT_C172396 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172396 NCIT_A7 NCIT_C104142 @default.
- NCIT_C172396 NCIT_NHC0 "C172396" @default.
- NCIT_C172396 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172396 NCIT_P107 "Cereblon E3 Ubiquitin Ligase Modulating Agent CC-99282" @default.
- NCIT_C172396 NCIT_P108 "Golcadomide" @default.
- NCIT_C172396 NCIT_P208 "CL1406350" @default.
- NCIT_C172396 NCIT_P210 "953769-46-5" @default.
- NCIT_C172396 NCIT_P319 "29HLR8Z5BR" @default.
- NCIT_C172396 NCIT_P322 "CTRP" @default.
- NCIT_C172396 NCIT_P322 "FDA" @default.
- NCIT_C172396 NCIT_P322 "GDC" @default.
- NCIT_C172396 NCIT_P329 "801633" @default.
- NCIT_C172396 NCIT_P330 "801633" @default.
- NCIT_C172396 NCIT_P375 "Cereblon E3 Ubiquitin Ligase Modulating Agent CC-99282" @default.
- NCIT_C172396 NCIT_P399 "801633" @default.
- NCIT_C172396 normalizedInformationContent "100" @default.
- NCIT_C172396 referenceCount "1" @default.
- NCIT_C172396 hasExactSynonym "BMS 986369" @default.
- NCIT_C172396 hasExactSynonym "BMS-986369" @default.
- NCIT_C172396 hasExactSynonym "BMS986369" @default.
- NCIT_C172396 hasExactSynonym "CC -99282" @default.
- NCIT_C172396 hasExactSynonym "CC 99282" @default.
- NCIT_C172396 hasExactSynonym "CC99282" @default.
- NCIT_C172396 hasExactSynonym "CelMod CC-99282" @default.
- NCIT_C172396 hasExactSynonym "Cereblon E3 Ubiquitin Ligase Modulating Agent CC-99282" @default.
- NCIT_C172396 hasExactSynonym "Cereblon E3 Ubiquitin Ligase Modulating Drug CC-99282" @default.
- NCIT_C172396 hasExactSynonym "Cereblon Modulator CC-99282" @default.
- NCIT_C172396 hasExactSynonym "GOLCADOMIDE" @default.
- NCIT_C172396 hasExactSynonym "Golcadomide" @default.
- NCIT_C172396 inSubset NCIT_C116977 @default.
- NCIT_C172396 inSubset NCIT_C116978 @default.
- NCIT_C172396 inSubset NCIT_C128784 @default.
- NCIT_C172396 inSubset NCIT_C157711 @default.
- NCIT_C172396 inSubset NCIT_C157712 @default.
- NCIT_C172396 inSubset NCIT_C176424 @default.
- NCIT_C172396 inSubset NCIT_C177537 @default.
- NCIT_C172396 inSubset NCIT_C63923 @default.
- NCIT_C172396 type Class @default.
- NCIT_C172396 isDefinedBy ncit.owl @default.
- NCIT_C172396 label "Golcadomide" @default.
- NCIT_C172396 subClassOf NCIT_C172396 @default.
- NCIT_C172396 subClassOf NCIT_C1908 @default.
- NCIT_C172396 subClassOf NCIT_C1909 @default.
- NCIT_C172396 subClassOf NCIT_C308 @default.