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- NCIT_C172443 IAO_0000115 "An Fc-engineered, humanized, bispecific hexamer formation-enhanced immunoglobulin (Ig) G1 monoclonal antibody that targets two separate epitopes on the tumor-associated antigen (TAA) CD37, with the E430G hexamerization-enhancing mutation, with potential immunomodulating and antineoplastic activities. Upon administration, ivicentamab specifically targets and binds to two non-overlapping CD37 epitopes, thereby inducing an assembly of antibody hexamers through intermolecular Fc-Fc interactions at the cell surface of CD37-overexpressing tumor cells. These hexamers recruit and activate C1, the first component of complement, thereby triggering the complement cascade which activates the immune system to induce complement-dependent cytotoxicity (CDC). In addition, the binding of ivicentamab to the CD37-overexpressing tumor cells also causes antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). CD37, a member of the tetraspanin superfamily of cell surface antigens, is expressed at high-levels on B cells and to a lesser extent on T cells and myeloid cells. The E430G mutation in the Fc domains enhances Fc-mediated IgG hexamerization upon cellular target binding, and enhances CDC." @default.
- NCIT_C172443 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172443 NCIT_A7 NCIT_C102769 @default.
- NCIT_C172443 NCIT_NHC0 "C172443" @default.
- NCIT_C172443 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C172443 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172443 NCIT_P107 "Ivicentamab" @default.
- NCIT_C172443 NCIT_P108 "Ivicentamab" @default.
- NCIT_C172443 NCIT_P208 "CL1406362" @default.
- NCIT_C172443 NCIT_P210 "2364496-42-2" @default.
- NCIT_C172443 NCIT_P319 "4O7JS64H45" @default.
- NCIT_C172443 NCIT_P322 "CTRP" @default.
- NCIT_C172443 NCIT_P322 "FDA" @default.
- NCIT_C172443 NCIT_P322 "GDC" @default.
- NCIT_C172443 NCIT_P329 "802024" @default.
- NCIT_C172443 NCIT_P330 "802024" @default.
- NCIT_C172443 NCIT_P375 "Anti-CD37 Bispecific Monoclonal Antibody GEN3009" @default.
- NCIT_C172443 NCIT_P399 "802024" @default.
- NCIT_C172443 NCIT_R124 NCIT_C17710 @default.
- NCIT_C172443 NCIT_R124 NCIT_C17828 @default.
- NCIT_C172443 NCIT_R124 NCIT_C18219 @default.
- NCIT_C172443 NCIT_R124 NCIT_C19986 @default.
- NCIT_C172443 NCIT_R124 NCIT_C40474 @default.
- NCIT_C172443 normalizedInformationContent "100" @default.
- NCIT_C172443 referenceCount "1" @default.
- NCIT_C172443 hasExactSynonym "Anti-CD37 Bispecific Monoclonal Antibody GEN3009" @default.
- NCIT_C172443 hasExactSynonym "DuoHexaBody-CD37 GEN3009" @default.
- NCIT_C172443 hasExactSynonym "DuoHexaBody-CD37" @default.
- NCIT_C172443 hasExactSynonym "GEN 3009" @default.
- NCIT_C172443 hasExactSynonym "GEN-3009" @default.
- NCIT_C172443 hasExactSynonym "GEN3009" @default.
- NCIT_C172443 hasExactSynonym "IVICENTAMAB" @default.
- NCIT_C172443 hasExactSynonym "Ivicentamab" @default.
- NCIT_C172443 inSubset NCIT_C116977 @default.
- NCIT_C172443 inSubset NCIT_C116978 @default.
- NCIT_C172443 inSubset NCIT_C128784 @default.
- NCIT_C172443 inSubset NCIT_C157711 @default.
- NCIT_C172443 inSubset NCIT_C157712 @default.
- NCIT_C172443 inSubset NCIT_C176424 @default.
- NCIT_C172443 inSubset NCIT_C177537 @default.
- NCIT_C172443 inSubset NCIT_C63923 @default.
- NCIT_C172443 type Class @default.
- NCIT_C172443 isDefinedBy ncit.owl @default.
- NCIT_C172443 label "Ivicentamab" @default.
- NCIT_C172443 subClassOf NCIT_C129821 @default.
- NCIT_C172443 subClassOf NCIT_C129822 @default.
- NCIT_C172443 subClassOf NCIT_C172443 @default.
- NCIT_C172443 subClassOf NCIT_C1908 @default.
- NCIT_C172443 subClassOf NCIT_C1909 @default.
- NCIT_C172443 subClassOf NCIT_C20401 @default.
- NCIT_C172443 subClassOf NCIT_C274 @default.
- NCIT_C172443 subClassOf NCIT_C307 @default.
- NCIT_C172443 subClassOf NCIT_C308 @default.