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- NCIT_C1725 IAO_0000115 "An indolinone-based small molecule selective tyrosine kinase inhibitor with potential antineoplastic activity. SU5402 blocks the activities of vascular endothelial growth factor receptors (VEGFR) and fibroblast growth factor 1 (FGFR1) via competing with ATP for the specific binding site within the catalytic domain of these receptors. This agent was shown to inhibit cell growth, decrease cell viability in dose-dependent manner, and induce apoptosis." @default.
- NCIT_C1725 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1725 NCIT_NHC0 "C1725" @default.
- NCIT_C1725 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1725 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1725 NCIT_P108 "Tyrosine Kinase Inhibitor SU5402" @default.
- NCIT_C1725 NCIT_P207 "C0538431" @default.
- NCIT_C1725 NCIT_P322 "GDC" @default.
- NCIT_C1725 NCIT_P366 "SU5402" @default.
- NCIT_C1725 NCIT_P368 "CHEBI:63449" @default.
- NCIT_C1725 NCIT_P375 "Tyrosine Kinase Inhibitor SU5402" @default.
- NCIT_C1725 normalizedInformationContent "100" @default.
- NCIT_C1725 referenceCount "1" @default.
- NCIT_C1725 hasExactSynonym "3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone" @default.
- NCIT_C1725 hasExactSynonym "SU 5402" @default.
- NCIT_C1725 hasExactSynonym "Tyrosine Kinase Inhibitor SU5402" @default.
- NCIT_C1725 inSubset NCIT_C128784 @default.
- NCIT_C1725 inSubset NCIT_C157711 @default.
- NCIT_C1725 inSubset NCIT_C157712 @default.
- NCIT_C1725 inSubset NCIT_C177537 @default.
- NCIT_C1725 type Class @default.
- NCIT_C1725 isDefinedBy ncit.owl @default.
- NCIT_C1725 label "Tyrosine Kinase Inhibitor SU5402" @default.
- NCIT_C1725 subClassOf NCIT_C129824 @default.
- NCIT_C1725 subClassOf NCIT_C129825 @default.
- NCIT_C1725 subClassOf NCIT_C1404 @default.
- NCIT_C1725 subClassOf NCIT_C1725 @default.
- NCIT_C1725 subClassOf NCIT_C1908 @default.
- NCIT_C1725 subClassOf NCIT_C1909 @default.
- NCIT_C1725 subClassOf NCIT_C1967 @default.
- NCIT_C1725 subClassOf NCIT_C2189 @default.
- NCIT_C1725 subClassOf NCIT_C274 @default.
- NCIT_C1725 subClassOf NCIT_C471 @default.