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- NCIT_C172652 IAO_0000115 "The calcium salt form of vidofludimus, an orally bioavailable inhibitor of dihydroorotate dehydrogenase (DHODH), with potential anti-inflammatory, immunomodulating and anti-viral activities. Upon administration, vidofludimus specifically targets, binds to and prevents the activation of DHODH. This prevents the fourth enzymatic step in de novo pyrimidine synthesis, leading to inhibition of transcriptional elongation, cell cycle arrest, and apoptosis in activated lymphocytes. DHODH inhibition also leads to metabolic stress in activated lymphocytes and inhibition of the release of proinflammatory cytokines including interleukin (IL)-17 (IL-17A and IL-17F) and interferon-gamma (IFNg), thereby reducing inflammation. In addition, DHODH inhibition may lead to host-based anti-viral activity against many viruses. DHODH, a mitochondrial enzyme that catalyzes the conversion of dihydroorotate (DHO) to orotate, is a key enzyme in pyrimidine de novo biosynthesis. Metabolically highly activated and rapidly proliferating lymphocytes and various virus infected cells require de novo synthesis to meet their needs for pyrimidines." @default.
- NCIT_C172652 NCIT_A6 NCIT_C152873 @default.
- NCIT_C172652 NCIT_NHC0 "C172652" @default.
- NCIT_C172652 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172652 NCIT_P108 "Vidofludimus Calcium Anhydrous" @default.
- NCIT_C172652 NCIT_P208 "CL1406732" @default.
- NCIT_C172652 NCIT_P210 "1354012-90-0" @default.
- NCIT_C172652 NCIT_P319 "FW5VY7926X" @default.
- NCIT_C172652 NCIT_P322 "FDA" @default.
- NCIT_C172652 normalizedInformationContent "100" @default.
- NCIT_C172652 referenceCount "1" @default.
- NCIT_C172652 hasExactSynonym "IMU 838" @default.
- NCIT_C172652 hasExactSynonym "IMU-838" @default.
- NCIT_C172652 hasExactSynonym "IMU838" @default.
- NCIT_C172652 hasExactSynonym "VIDOFLUDIMUS CALCIUM ANHYDROUS" @default.
- NCIT_C172652 hasExactSynonym "Vidofludimus Calcium Anhydrous" @default.
- NCIT_C172652 hasExactSynonym "Vidofludimus Calcium" @default.
- NCIT_C172652 inSubset NCIT_C173381 @default.
- NCIT_C172652 inSubset NCIT_C173383 @default.
- NCIT_C172652 inSubset NCIT_C63923 @default.
- NCIT_C172652 type Class @default.
- NCIT_C172652 isDefinedBy ncit.owl @default.
- NCIT_C172652 label "Vidofludimus Calcium Anhydrous" @default.
- NCIT_C172652 subClassOf NCIT_C172652 @default.
- NCIT_C172652 subClassOf NCIT_C1908 @default.
- NCIT_C172652 subClassOf NCIT_C1909 @default.
- NCIT_C172652 subClassOf NCIT_C2169 @default.
- NCIT_C172652 subClassOf NCIT_C308 @default.
- NCIT_C172652 subClassOf NCIT_C471 @default.
- NCIT_C172652 subClassOf NCIT_C574 @default.