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- NCIT_C172746 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR), CAT-41BBz CAR, targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, obecabtagene autoleucel target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The CAT-41BBz CAR has a faster off-rate compared with FMC63-41BBz CAR. This may minimize cytokine release and reduce toxicities, and enhance persistence of the CAR T-cells." @default.
- NCIT_C172746 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172746 NCIT_A7 NCIT_C38894 @default.
- NCIT_C172746 NCIT_NHC0 "C172746" @default.
- NCIT_C172746 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172746 NCIT_P107 "Obecabtagene Autoleucel" @default.
- NCIT_C172746 NCIT_P108 "Obecabtagene Autoleucel" @default.
- NCIT_C172746 NCIT_P208 "CL1406598" @default.
- NCIT_C172746 NCIT_P319 "760HJB0YRD" @default.
- NCIT_C172746 NCIT_P322 "CTRP" @default.
- NCIT_C172746 NCIT_P322 "FDA" @default.
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- NCIT_C172746 NCIT_P329 "801949" @default.
- NCIT_C172746 NCIT_P330 "801949" @default.
- NCIT_C172746 NCIT_P375 "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells AUTO1" @default.
- NCIT_C172746 NCIT_P399 "801949" @default.
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- NCIT_C172746 NCIT_R72 NCIT_C104083 @default.
- NCIT_C172746 NCIT_R72 NCIT_C12219 @default.
- NCIT_C172746 NCIT_R72 NCIT_C12476 @default.
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- NCIT_C172746 NCIT_R72 NCIT_C32725 @default.
- NCIT_C172746 NCIT_R72 NCIT_C33061 @default.
- NCIT_C172746 NCIT_R72 NCIT_C38434 @default.
- NCIT_C172746 NCIT_R72 NCIT_C38439 @default.
- NCIT_C172746 NCIT_R72 NCIT_C39567 @default.
- NCIT_C172746 NCIT_R72 NCIT_C39568 @default.
- NCIT_C172746 normalizedInformationContent "100" @default.
- NCIT_C172746 referenceCount "1" @default.
- NCIT_C172746 hasExactSynonym "AUTO 1" @default.
- NCIT_C172746 hasExactSynonym "AUTO-1" @default.
- NCIT_C172746 hasExactSynonym "AUTO1 CAR-T Cells" @default.
- NCIT_C172746 hasExactSynonym "AUTO1" @default.
- NCIT_C172746 hasExactSynonym "Autologous Anti-CD19 CAR T-cells AUTO1" @default.
- NCIT_C172746 hasExactSynonym "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells AUTO1" @default.
- NCIT_C172746 hasExactSynonym "Autologous Anti-CD19 Chimeric Antigen Receptor T-lymphocytes AUTO1" @default.
- NCIT_C172746 hasExactSynonym "Autologous CD19-targeted CAR T-cells AUTO1" @default.
- NCIT_C172746 hasExactSynonym "CD19CAR T-cells AUTO1" @default.
- NCIT_C172746 hasExactSynonym "CD19CAT-41BBZ CAR T-cells AUTO1" @default.
- NCIT_C172746 hasExactSynonym "OBECABTAGENE AUTOLEUCEL" @default.
- NCIT_C172746 hasExactSynonym "Obe-cel" @default.
- NCIT_C172746 hasExactSynonym "Obecabtagene Autoleucel" @default.
- NCIT_C172746 inSubset NCIT_C116977 @default.
- NCIT_C172746 inSubset NCIT_C116978 @default.
- NCIT_C172746 inSubset NCIT_C128784 @default.
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- NCIT_C172746 type Class @default.
- NCIT_C172746 isDefinedBy ncit.owl @default.
- NCIT_C172746 label "Obecabtagene Autoleucel" @default.
- NCIT_C172746 subClassOf NCIT_C129820 @default.
- NCIT_C172746 subClassOf NCIT_C129821 @default.
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- NCIT_C172746 subClassOf NCIT_C137999 @default.
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- NCIT_C172746 subClassOf NCIT_C1908 @default.
- NCIT_C172746 subClassOf NCIT_C1909 @default.
- NCIT_C172746 subClassOf NCIT_C1962 @default.
- NCIT_C172746 subClassOf NCIT_C200766 @default.
- NCIT_C172746 subClassOf NCIT_C274 @default.
- NCIT_C172746 subClassOf NCIT_C28681 @default.
- NCIT_C172746 subClassOf NCIT_C307 @default.
- NCIT_C172746 subClassOf NCIT_C308 @default.