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- NCIT_C172805 IAO_0000115 "An orally bioavailable inhibitor of the extracellular signal-regulated kinases 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, ERK1/2 inhibitor HH2710 specifically targets, binds to and inhibits the activity of the serine/threonine-protein kinases ERK1 and ERK2, thereby preventing the phosphorylation of ERK1/2 substrates and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent proliferation and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream targets. It plays a key role in the proliferation, differentiation and survival of tumor cells." @default.
- NCIT_C172805 NCIT_A32 NCIT_C1909 @default.
- NCIT_C172805 NCIT_A7 NCIT_C17408 @default.
- NCIT_C172805 NCIT_A7 NCIT_C17589 @default.
- NCIT_C172805 NCIT_NHC0 "C172805" @default.
- NCIT_C172805 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172805 NCIT_P107 "ERK1/2 Inhibitor HH2710" @default.
- NCIT_C172805 NCIT_P108 "ERK1/2 Inhibitor HH2710" @default.
- NCIT_C172805 NCIT_P208 "CL1406865" @default.
- NCIT_C172805 NCIT_P322 "CTRP" @default.
- NCIT_C172805 NCIT_P322 "GDC" @default.
- NCIT_C172805 NCIT_P329 "802029" @default.
- NCIT_C172805 NCIT_P330 "802029" @default.
- NCIT_C172805 NCIT_P375 "ERK1/2 Inhibitor HH2710" @default.
- NCIT_C172805 NCIT_P399 "802029" @default.
- NCIT_C172805 normalizedInformationContent "100" @default.
- NCIT_C172805 referenceCount "1" @default.
- NCIT_C172805 hasExactSynonym "ERK Inhibitor HH2710" @default.
- NCIT_C172805 hasExactSynonym "ERK1/2 Inhibitor HH2710" @default.
- NCIT_C172805 hasExactSynonym "Extracellular Signal-regulated Kinase 1/2 Inhibitor HH2710" @default.
- NCIT_C172805 hasExactSynonym "HH 2710" @default.
- NCIT_C172805 hasExactSynonym "HH-2710" @default.
- NCIT_C172805 hasExactSynonym "HH2710" @default.
- NCIT_C172805 inSubset NCIT_C116977 @default.
- NCIT_C172805 inSubset NCIT_C116978 @default.
- NCIT_C172805 inSubset NCIT_C128784 @default.
- NCIT_C172805 inSubset NCIT_C157711 @default.
- NCIT_C172805 inSubset NCIT_C157712 @default.
- NCIT_C172805 inSubset NCIT_C176424 @default.
- NCIT_C172805 inSubset NCIT_C177537 @default.
- NCIT_C172805 type Class @default.
- NCIT_C172805 isDefinedBy ncit.owl @default.
- NCIT_C172805 label "ERK1/2 Inhibitor HH2710" @default.
- NCIT_C172805 subClassOf NCIT_C129824 @default.
- NCIT_C172805 subClassOf NCIT_C129825 @default.
- NCIT_C172805 subClassOf NCIT_C1404 @default.
- NCIT_C172805 subClassOf NCIT_C172805 @default.
- NCIT_C172805 subClassOf NCIT_C174048 @default.
- NCIT_C172805 subClassOf NCIT_C1908 @default.
- NCIT_C172805 subClassOf NCIT_C1909 @default.
- NCIT_C172805 subClassOf NCIT_C2189 @default.
- NCIT_C172805 subClassOf NCIT_C274 @default.
- NCIT_C172805 subClassOf NCIT_C471 @default.
- NCIT_C172805 subClassOf NCIT_C61074 @default.