Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C172825> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- NCIT_C172825 IAO_0000115 "A low-dose formulation of aldesleukin, a recombinant analog of the human endogenous cytokine interleukin-2 (IL-2), with potential immunoregulatory activity. Upon administration of low-dose aldesleukin ILT-101, this agent binds to and activates the IL-2 receptor (IL2R), thereby activating IL2R-mediated signaling. This enhances the expansion and stimulation of regulatory T cells (Tregs). This prevents excessive inflammation and autoimmunity. It also blocks the differentiation of CD4 naïve T cells into follicular helper or proinflammatory helper 17 (Th17) T cells. Tregs, a subpopulation of CD4+ T cells, plays a key role in the control of immune responses and T-cell immune tolerance. Activation of IL2R with low dose IL-2 preferentially induces Tregs development and activation while activation of IL2R with high dose IL-2 induces the activation of T effector (Teff) cells." @default.
- NCIT_C172825 NCIT_NHC0 "C172825" @default.
- NCIT_C172825 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C172825 NCIT_P108 "Low-dose Aldesleukin ILT-101" @default.
- NCIT_C172825 NCIT_P208 "CL1406857" @default.
- NCIT_C172825 NCIT_R124 NCIT_C17828 @default.
- NCIT_C172825 NCIT_R124 NCIT_C18992 @default.
- NCIT_C172825 NCIT_R124 NCIT_C19143 @default.
- NCIT_C172825 NCIT_R124 NCIT_C21124 @default.
- NCIT_C172825 NCIT_R124 NCIT_C40702 @default.
- NCIT_C172825 NCIT_R124 NCIT_C45547 @default.
- NCIT_C172825 NCIT_R125 NCIT_C16395 @default.
- NCIT_C172825 NCIT_R125 NCIT_C17710 @default.
- NCIT_C172825 NCIT_R125 NCIT_C17828 @default.
- NCIT_C172825 NCIT_R125 NCIT_C17937 @default.
- NCIT_C172825 NCIT_R125 NCIT_C18081 @default.
- NCIT_C172825 NCIT_R125 NCIT_C18095 @default.
- NCIT_C172825 NCIT_R125 NCIT_C18839 @default.
- NCIT_C172825 NCIT_R125 NCIT_C20480 @default.
- NCIT_C172825 NCIT_R125 NCIT_C20751 @default.
- NCIT_C172825 NCIT_R125 NCIT_C21049 @default.
- NCIT_C172825 NCIT_R125 NCIT_C21050 @default.
- NCIT_C172825 NCIT_R125 NCIT_C21124 @default.
- NCIT_C172825 NCIT_R125 NCIT_C26280 @default.
- NCIT_C172825 NCIT_R125 NCIT_C28498 @default.
- NCIT_C172825 NCIT_R125 NCIT_C40767 @default.
- NCIT_C172825 NCIT_R125 NCIT_C40833 @default.
- NCIT_C172825 NCIT_R125 NCIT_C40912 @default.
- NCIT_C172825 NCIT_R146 NCIT_C104679 @default.
- NCIT_C172825 NCIT_R146 NCIT_C21176 @default.
- NCIT_C172825 NCIT_R146 NCIT_C26548 @default.
- NCIT_C172825 normalizedInformationContent "100" @default.
- NCIT_C172825 referenceCount "1" @default.
- NCIT_C172825 hasExactSynonym "ILT 101" @default.
- NCIT_C172825 hasExactSynonym "ILT-101" @default.
- NCIT_C172825 hasExactSynonym "ILT101" @default.
- NCIT_C172825 hasExactSynonym "Low-dose Aldesleukin ILT-101" @default.
- NCIT_C172825 hasExactSynonym "Low-dose IL-2 ILT-101" @default.
- NCIT_C172825 inSubset NCIT_C173381 @default.
- NCIT_C172825 inSubset NCIT_C173383 @default.
- NCIT_C172825 type Class @default.
- NCIT_C172825 isDefinedBy ncit.owl @default.
- NCIT_C172825 label "Low-dose Aldesleukin ILT-101" @default.
- NCIT_C172825 subClassOf NCIT_C1283 @default.
- NCIT_C172825 subClassOf NCIT_C172825 @default.
- NCIT_C172825 subClassOf NCIT_C1908 @default.
- NCIT_C172825 subClassOf NCIT_C1909 @default.
- NCIT_C172825 subClassOf NCIT_C307 @default.
- NCIT_C172825 subClassOf NCIT_C308 @default.
- NCIT_C172825 subClassOf NCIT_C587 @default.
- NCIT_C172825 subClassOf NCIT_C593 @default.