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- NCIT_C173020 IAO_0000115 "A formulation consisting of lipid nanoparticle (LNP) encapsulating messenger RNA (mRNA) encoding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunizing and anti-COVID-19 activities. Upon injection, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated immune response. This may provide active immunization against SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus." @default.
- NCIT_C173020 NCIT_NHC0 "C173020" @default.
- NCIT_C173020 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C173020 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173020 NCIT_P108 "SARS-CoV-2 mRNA Vaccine BNT162" @default.
- NCIT_C173020 NCIT_P208 "CL1406793" @default.
- NCIT_C173020 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C173020 referenceCount "6" @default.
- NCIT_C173020 hasExactSynonym "BNT 162" @default.
- NCIT_C173020 hasExactSynonym "BNT-162" @default.
- NCIT_C173020 hasExactSynonym "BNT162 COVID-19 Vaccine" @default.
- NCIT_C173020 hasExactSynonym "BNT162 SARS-CoV-2 Vaccine" @default.
- NCIT_C173020 hasExactSynonym "BNT162" @default.
- NCIT_C173020 hasExactSynonym "SARS-CoV-2 mRNA Vaccine BNT162" @default.
- NCIT_C173020 inSubset NCIT_C173381 @default.
- NCIT_C173020 inSubset NCIT_C173383 @default.
- NCIT_C173020 type Class @default.
- NCIT_C173020 isDefinedBy ncit.owl @default.
- NCIT_C173020 label "SARS-CoV-2 mRNA Vaccine BNT162" @default.
- NCIT_C173020 subClassOf NCIT_C172787 @default.
- NCIT_C173020 subClassOf NCIT_C173020 @default.
- NCIT_C173020 subClassOf NCIT_C173023 @default.
- NCIT_C173020 subClassOf NCIT_C181140 @default.
- NCIT_C173020 subClassOf NCIT_C1908 @default.
- NCIT_C173020 subClassOf NCIT_C1909 @default.
- NCIT_C173020 subClassOf NCIT_C307 @default.
- NCIT_C173020 subClassOf NCIT_C308 @default.
- NCIT_C173020 subClassOf NCIT_C923 @default.