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- NCIT_C173054 IAO_0000115 "A formulation consisting of lipid nanoparticle (LNP) encapsulating nucleoside-modified messenger RNA (modRNA) encoding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunizing and anti-COVID-19 activities. Upon injection of SARS-CoV-2 SP modRNA LNP vaccine BNT162a1, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated immune response. This may provide active immunization against SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus." @default.
- NCIT_C173054 NCIT_NHC0 "C173054" @default.
- NCIT_C173054 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C173054 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173054 NCIT_P108 "SARS-CoV-2 SP modRNA LNP vaccine BNT162a1" @default.
- NCIT_C173054 NCIT_P208 "CL1640890" @default.
- NCIT_C173054 NCIT_P210 "2417899-74-0" @default.
- NCIT_C173054 NCIT_P319 "N38TVC63NU" @default.
- NCIT_C173054 NCIT_P322 "FDA" @default.
- NCIT_C173054 normalizedInformationContent "100" @default.
- NCIT_C173054 referenceCount "1" @default.
- NCIT_C173054 hasExactSynonym "BNT 162a1" @default.
- NCIT_C173054 hasExactSynonym "BNT-162A1" @default.
- NCIT_C173054 hasExactSynonym "BNT-162a1" @default.
- NCIT_C173054 hasExactSynonym "BNT1162a1 SARS-CoV-2 Vaccine" @default.
- NCIT_C173054 hasExactSynonym "BNT162a1 COVID-19 Vaccine" @default.
- NCIT_C173054 hasExactSynonym "BNT162a1" @default.
- NCIT_C173054 hasExactSynonym "SARS-CoV-2 SP modRNA LNP vaccine BNT162a1" @default.
- NCIT_C173054 inSubset NCIT_C173381 @default.
- NCIT_C173054 inSubset NCIT_C173383 @default.
- NCIT_C173054 inSubset NCIT_C63923 @default.
- NCIT_C173054 type Class @default.
- NCIT_C173054 isDefinedBy ncit.owl @default.
- NCIT_C173054 label "SARS-CoV-2 SP modRNA LNP vaccine BNT162a1" @default.
- NCIT_C173054 subClassOf NCIT_C172787 @default.
- NCIT_C173054 subClassOf NCIT_C173020 @default.
- NCIT_C173054 subClassOf NCIT_C173023 @default.
- NCIT_C173054 subClassOf NCIT_C173054 @default.
- NCIT_C173054 subClassOf NCIT_C181140 @default.
- NCIT_C173054 subClassOf NCIT_C1908 @default.
- NCIT_C173054 subClassOf NCIT_C1909 @default.
- NCIT_C173054 subClassOf NCIT_C307 @default.
- NCIT_C173054 subClassOf NCIT_C308 @default.
- NCIT_C173054 subClassOf NCIT_C923 @default.