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- NCIT_C173056 IAO_0000115 "A formulation consisting of lipid nanoparticle (LNP) encapsulating a specific form of messenger RNA encoding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunizing and anti-COVID-19 activities. Upon injection of pidacmeran, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated immune response. This may provide active immunization against SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus." @default.
- NCIT_C173056 NCIT_NHC0 "C173056" @default.
- NCIT_C173056 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C173056 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173056 NCIT_P108 "Pidacmeran" @default.
- NCIT_C173056 NCIT_P208 "CL1406828" @default.
- NCIT_C173056 NCIT_P210 "2417904-10-8" @default.
- NCIT_C173056 NCIT_P319 "6FH8H9CL41" @default.
- NCIT_C173056 NCIT_P322 "FDA" @default.
- NCIT_C173056 normalizedInformationContent "100" @default.
- NCIT_C173056 referenceCount "1" @default.
- NCIT_C173056 hasExactSynonym "BNT 162c2" @default.
- NCIT_C173056 hasExactSynonym "BNT-162c2" @default.
- NCIT_C173056 hasExactSynonym "BNT1162c2 SARS-CoV-2 Vaccine" @default.
- NCIT_C173056 hasExactSynonym "BNT162c2 COVID-19 Vaccine" @default.
- NCIT_C173056 hasExactSynonym "BNT162c2" @default.
- NCIT_C173056 hasExactSynonym "PIDACMERAN" @default.
- NCIT_C173056 hasExactSynonym "Pidacmeran" @default.
- NCIT_C173056 inSubset NCIT_C173381 @default.
- NCIT_C173056 inSubset NCIT_C173383 @default.
- NCIT_C173056 inSubset NCIT_C63923 @default.
- NCIT_C173056 type Class @default.
- NCIT_C173056 isDefinedBy ncit.owl @default.
- NCIT_C173056 label "Pidacmeran" @default.
- NCIT_C173056 subClassOf NCIT_C172787 @default.
- NCIT_C173056 subClassOf NCIT_C173020 @default.
- NCIT_C173056 subClassOf NCIT_C173023 @default.
- NCIT_C173056 subClassOf NCIT_C173056 @default.
- NCIT_C173056 subClassOf NCIT_C181140 @default.
- NCIT_C173056 subClassOf NCIT_C1908 @default.
- NCIT_C173056 subClassOf NCIT_C1909 @default.
- NCIT_C173056 subClassOf NCIT_C307 @default.
- NCIT_C173056 subClassOf NCIT_C308 @default.
- NCIT_C173056 subClassOf NCIT_C923 @default.