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- NCIT_C173153 IAO_0000115 "A preparation of human allogeneic T-lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous TCR and major histocompatibility complex (MHC) class I molecules and modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD70 CAR T-cells CTX130 recognize and bind to CD70-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Disruption of endogenous TCR prevents graft-versus-host disease (GvHD); the disruption of MHC class I molecules increases the persistence of the CAR T-cells." @default.
- NCIT_C173153 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173153 NCIT_A7 NCIT_C104079 @default.
- NCIT_C173153 NCIT_NHC0 "C173153" @default.
- NCIT_C173153 NCIT_P106 "Cell" @default.
- NCIT_C173153 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173153 NCIT_P107 "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130" @default.
- NCIT_C173153 NCIT_P108 "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130" @default.
- NCIT_C173153 NCIT_P208 "CL1407020" @default.
- NCIT_C173153 NCIT_P322 "CTRP" @default.
- NCIT_C173153 NCIT_P322 "GDC" @default.
- NCIT_C173153 NCIT_P329 "802058" @default.
- NCIT_C173153 NCIT_P330 "802058" @default.
- NCIT_C173153 NCIT_P375 "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130" @default.
- NCIT_C173153 NCIT_P399 "802058" @default.
- NCIT_C173153 normalizedInformationContent "100" @default.
- NCIT_C173153 referenceCount "1" @default.
- NCIT_C173153 hasExactSynonym "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130" @default.
- NCIT_C173153 hasExactSynonym "Allogeneic CRISPR-Cas9-engineered T Cells CTX130" @default.
- NCIT_C173153 hasExactSynonym "CRISPR/Cas9 Gene-edited Allogeneic Anti-CD70 CAR-T Cells CTX130" @default.
- NCIT_C173153 hasExactSynonym "CTX 130" @default.
- NCIT_C173153 hasExactSynonym "CTX-130" @default.
- NCIT_C173153 hasExactSynonym "CTX130" @default.
- NCIT_C173153 hasExactSynonym "Donor-derived Gene-edited Allogeneic CAR-T Cells CTX130" @default.
- NCIT_C173153 inSubset NCIT_C116977 @default.
- NCIT_C173153 inSubset NCIT_C116978 @default.
- NCIT_C173153 inSubset NCIT_C128784 @default.
- NCIT_C173153 inSubset NCIT_C157711 @default.
- NCIT_C173153 inSubset NCIT_C157712 @default.
- NCIT_C173153 inSubset NCIT_C176424 @default.
- NCIT_C173153 inSubset NCIT_C177537 @default.
- NCIT_C173153 type Class @default.
- NCIT_C173153 isDefinedBy ncit.owl @default.
- NCIT_C173153 label "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130" @default.
- NCIT_C173153 subClassOf NCIT_C129820 @default.
- NCIT_C173153 subClassOf NCIT_C129821 @default.
- NCIT_C173153 subClassOf NCIT_C129826 @default.
- NCIT_C173153 subClassOf NCIT_C137999 @default.
- NCIT_C173153 subClassOf NCIT_C142078 @default.
- NCIT_C173153 subClassOf NCIT_C154231 @default.
- NCIT_C173153 subClassOf NCIT_C173153 @default.
- NCIT_C173153 subClassOf NCIT_C1908 @default.
- NCIT_C173153 subClassOf NCIT_C1909 @default.
- NCIT_C173153 subClassOf NCIT_C1962 @default.
- NCIT_C173153 subClassOf NCIT_C200765 @default.
- NCIT_C173153 subClassOf NCIT_C201176 @default.
- NCIT_C173153 subClassOf NCIT_C274 @default.
- NCIT_C173153 subClassOf NCIT_C28676 @default.
- NCIT_C173153 subClassOf NCIT_C307 @default.
- NCIT_C173153 subClassOf NCIT_C308 @default.