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- NCIT_C17316 IAO_0000115 "Human MCF2 Oncoprotein is a product of a mutated variant (Oncogene MCF2) of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at 15q15-q23. MCF2 Oncoprotein disrupts normal cell function." @default.
- NCIT_C17316 NCIT_NHC0 "C17316" @default.
- NCIT_C17316 NCIT_P100 "311030" @default.
- NCIT_C17316 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C17316 NCIT_P106 "Biologically Active Substance" @default.
- NCIT_C17316 NCIT_P108 "DBL Oncoprotein" @default.
- NCIT_C17316 NCIT_P207 "C0069500" @default.
- NCIT_C17316 NCIT_P366 "DBL_Oncoprotein" @default.
- NCIT_C17316 NCIT_P93 "P10911" @default.
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- NCIT_C17316 NCIT_R49 NCIT_C13040 @default.
- NCIT_C17316 NCIT_R49 NCIT_C32221 @default.
- NCIT_C17316 NCIT_R49 NCIT_C33966 @default.
- NCIT_C17316 NCIT_R49 NCIT_C34061 @default.
- NCIT_C17316 NCIT_R53 NCIT_C16956 @default.
- NCIT_C17316 NCIT_R53 NCIT_C17133 @default.
- NCIT_C17316 NCIT_R53 NCIT_C17828 @default.
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- NCIT_C17316 NCIT_R53 NCIT_C21188 @default.
- NCIT_C17316 NCIT_R54 NCIT_C16612 @default.
- NCIT_C17316 NCIT_R54 NCIT_C16936 @default.
- NCIT_C17316 NCIT_R54 NCIT_C18335 @default.
- NCIT_C17316 NCIT_R54 NCIT_C19540 @default.
- NCIT_C17316 NCIT_R54 NCIT_C20921 @default.
- NCIT_C17316 NCIT_R54 NCIT_C45489 @default.
- NCIT_C17316 normalizedInformationContent "100" @default.
- NCIT_C17316 referenceCount "1" @default.
- NCIT_C17316 hasExactSynonym "DBL Oncoprotein" @default.
- NCIT_C17316 hasExactSynonym "DBL" @default.
- NCIT_C17316 hasExactSynonym "MCF2 Oncoprotein" @default.
- NCIT_C17316 hasExactSynonym "MCF2" @default.
- NCIT_C17316 hasExactSynonym "p66" @default.
- NCIT_C17316 type Class @default.
- NCIT_C17316 isDefinedBy ncit.owl @default.
- NCIT_C17316 label "DBL Oncoprotein" @default.
- NCIT_C17316 subClassOf B36f541a4a740bd67d86005d1a6daa568 @default.
- NCIT_C17316 subClassOf B4bb9a992f0a58d9ed87975253190e94a @default.
- NCIT_C17316 subClassOf B7330fd185e35abc18769d26423e7e17f @default.
- NCIT_C17316 subClassOf Ba95d66f054027f07f48bdd5b8f7a0cbe @default.
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- NCIT_C17316 subClassOf NCIT_C16934 @default.
- NCIT_C17316 subClassOf NCIT_C17021 @default.
- NCIT_C17316 subClassOf NCIT_C17316 @default.
- NCIT_C17316 subClassOf NCIT_C20027 @default.
- NCIT_C17316 subClassOf NCIT_C26548 @default.