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- NCIT_C173165 IAO_0000115 "A bifunctional monoclonal antibody targeting both the receptor tyrosine kinase epidermal growth factor receptor (EGFR) and the pro-inflammatory cytokine human transforming growth factor beta (TGF-beta; TGFb), with potential antineoplastic activity. Upon administration of EGFR/TGFb fusion monoclonal antibody BCA101, the anti-EGFR moiety targets, binds to and prevents activation of EGFR-mediated signaling. This leads to an inhibition of EGFR-dependent downstream pathways and EGFR-dependent tumor cell proliferation and metastasis. The anti-TGFb moiety targets and binds to TGFb, thereby preventing the activation of TGFb-mediated signaling pathways. This may inhibit the proliferation of tumor cells in which TGFb is overactivated. EGFR and TGFb, mutated and/or overexpressed on the surfaces of various tumor cell types, play key roles in tumor cell proliferation and progression." @default.
- NCIT_C173165 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173165 NCIT_A7 NCIT_C17068 @default.
- NCIT_C173165 NCIT_A7 NCIT_C20457 @default.
- NCIT_C173165 NCIT_A7 NCIT_C20458 @default.
- NCIT_C173165 NCIT_A7 NCIT_C20459 @default.
- NCIT_C173165 NCIT_NHC0 "C173165" @default.
- NCIT_C173165 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C173165 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C173165 NCIT_P107 "EGFR/TGFb Fusion Monoclonal Antibody BCA101" @default.
- NCIT_C173165 NCIT_P108 "EGFR/TGFb Fusion Monoclonal Antibody BCA101" @default.
- NCIT_C173165 NCIT_P208 "CL1407043" @default.
- NCIT_C173165 NCIT_P319 "LZ88YF62H2" @default.
- NCIT_C173165 NCIT_P322 "CTRP" @default.
- NCIT_C173165 NCIT_P322 "FDA" @default.
- NCIT_C173165 NCIT_P322 "GDC" @default.
- NCIT_C173165 NCIT_P329 "802059" @default.
- NCIT_C173165 NCIT_P330 "802059" @default.
- NCIT_C173165 NCIT_P375 "EGFR/TGFb Fusion Monoclonal Antibody BCA101" @default.
- NCIT_C173165 NCIT_P399 "802059" @default.
- NCIT_C173165 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173165 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173165 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173165 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173165 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173165 normalizedInformationContent "100" @default.
- NCIT_C173165 referenceCount "1" @default.
- NCIT_C173165 hasExactSynonym "Anti-EGFR/TGFb Bispecific Monoclonal Antibody BCA101" @default.
- NCIT_C173165 hasExactSynonym "Anti-EGFR/TGFb Monoclonal Antibody BCA101" @default.
- NCIT_C173165 hasExactSynonym "BCA 101" @default.
- NCIT_C173165 hasExactSynonym "BCA-101" @default.
- NCIT_C173165 hasExactSynonym "BCA101" @default.
- NCIT_C173165 hasExactSynonym "EGFR/TGFb Fusion Monoclonal Antibody BCA101" @default.
- NCIT_C173165 inSubset NCIT_C116977 @default.
- NCIT_C173165 inSubset NCIT_C116978 @default.
- NCIT_C173165 inSubset NCIT_C128784 @default.
- NCIT_C173165 inSubset NCIT_C157711 @default.
- NCIT_C173165 inSubset NCIT_C157712 @default.
- NCIT_C173165 inSubset NCIT_C176424 @default.
- NCIT_C173165 inSubset NCIT_C177537 @default.
- NCIT_C173165 inSubset NCIT_C63923 @default.
- NCIT_C173165 type Class @default.
- NCIT_C173165 isDefinedBy ncit.owl @default.
- NCIT_C173165 label "EGFR/TGFb Fusion Monoclonal Antibody BCA101" @default.
- NCIT_C173165 subClassOf NCIT_C1454 @default.
- NCIT_C173165 subClassOf NCIT_C173165 @default.
- NCIT_C173165 subClassOf NCIT_C1908 @default.
- NCIT_C173165 subClassOf NCIT_C1909 @default.
- NCIT_C173165 subClassOf NCIT_C20401 @default.
- NCIT_C173165 subClassOf NCIT_C28227 @default.
- NCIT_C173165 subClassOf NCIT_C307 @default.
- NCIT_C173165 subClassOf NCIT_C308 @default.