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- NCIT_C173363 IAO_0000115 "An episcleral plaque containing sustained-release (SR) topotecan, a semisynthetic derivative of camptothecin and a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic activity. Upon local application of the topotecan SR episcleral plaque to the eye, topotecan is released in a sustained manner and inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The episcleral plaque allows for local delivery of topotecan for the potential treatment of retinoblastoma." @default.
- NCIT_C173363 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173363 NCIT_A7 NCIT_C16516 @default.
- NCIT_C173363 NCIT_NHC0 "C173363" @default.
- NCIT_C173363 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173363 NCIT_P107 "Topotecan Sustained-Release Episcleral Plaque" @default.
- NCIT_C173363 NCIT_P108 "Topotecan Sustained-release Episcleral Plaque" @default.
- NCIT_C173363 NCIT_P208 "CL1407190" @default.
- NCIT_C173363 NCIT_P322 "CTRP" @default.
- NCIT_C173363 NCIT_P322 "GDC" @default.
- NCIT_C173363 NCIT_P329 "801808" @default.
- NCIT_C173363 NCIT_P330 "801808" @default.
- NCIT_C173363 NCIT_P375 "Topotecan Sustained-release Episcleral Plaque" @default.
- NCIT_C173363 NCIT_P399 "801808" @default.
- NCIT_C173363 normalizedInformationContent "100" @default.
- NCIT_C173363 referenceCount "1" @default.
- NCIT_C173363 hasExactSynonym "Chemoplaque" @default.
- NCIT_C173363 hasExactSynonym "Episcleral Topotecan" @default.
- NCIT_C173363 hasExactSynonym "SR Topotecan Episcleral Plaque" @default.
- NCIT_C173363 hasExactSynonym "Sustained Release Episcleral Topotecan" @default.
- NCIT_C173363 hasExactSynonym "Sustained-release Topotecan Episcleral Plaque" @default.
- NCIT_C173363 hasExactSynonym "Topotecan SR Episcleral Plaque" @default.
- NCIT_C173363 hasExactSynonym "Topotecan Sustained-Release Episcleral Plaque" @default.
- NCIT_C173363 hasExactSynonym "Topotecan Sustained-release Episcleral Plaque" @default.
- NCIT_C173363 hasExactSynonym "Transscleral Topotecan" @default.
- NCIT_C173363 inSubset NCIT_C116977 @default.
- NCIT_C173363 inSubset NCIT_C116978 @default.
- NCIT_C173363 inSubset NCIT_C128784 @default.
- NCIT_C173363 inSubset NCIT_C157711 @default.
- NCIT_C173363 inSubset NCIT_C157712 @default.
- NCIT_C173363 inSubset NCIT_C176424 @default.
- NCIT_C173363 inSubset NCIT_C177537 @default.
- NCIT_C173363 type Class @default.
- NCIT_C173363 isDefinedBy ncit.owl @default.
- NCIT_C173363 label "Topotecan Sustained-release Episcleral Plaque" @default.
- NCIT_C173363 subClassOf NCIT_C129824 @default.
- NCIT_C173363 subClassOf NCIT_C129825 @default.
- NCIT_C173363 subClassOf NCIT_C173363 @default.
- NCIT_C173363 subClassOf NCIT_C1748 @default.
- NCIT_C173363 subClassOf NCIT_C1904 @default.
- NCIT_C173363 subClassOf NCIT_C1908 @default.
- NCIT_C173363 subClassOf NCIT_C1909 @default.
- NCIT_C173363 subClassOf NCIT_C2189 @default.
- NCIT_C173363 subClassOf NCIT_C274 @default.
- NCIT_C173363 subClassOf NCIT_C2843 @default.
- NCIT_C173363 subClassOf NCIT_C471 @default.