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- NCIT_C173369 IAO_0000115 "A recombinant immunoglobulin G1 (IgG1) bispecific antibody targeting both the human T-cell surface antigen CD3 and oncofetal antigen 5T4, with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD3/anti-5T4 bispecific antibody GEN1044 simultaneously targets and binds to CD3 expressed on T-cells and 5T4 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness." @default.
- NCIT_C173369 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173369 NCIT_NHC0 "C173369" @default.
- NCIT_C173369 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173369 NCIT_P107 "Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044" @default.
- NCIT_C173369 NCIT_P108 "Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044" @default.
- NCIT_C173369 NCIT_P208 "CL1407193" @default.
- NCIT_C173369 NCIT_P322 "CTRP" @default.
- NCIT_C173369 NCIT_P322 "GDC" @default.
- NCIT_C173369 NCIT_P329 "801833" @default.
- NCIT_C173369 NCIT_P330 "801833" @default.
- NCIT_C173369 NCIT_P375 "Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044" @default.
- NCIT_C173369 NCIT_P399 "801833" @default.
- NCIT_C173369 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173369 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173369 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173369 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173369 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173369 normalizedInformationContent "100" @default.
- NCIT_C173369 referenceCount "1" @default.
- NCIT_C173369 hasExactSynonym "Anti-CD3/5T4 Bispecific Antibody GEN1044" @default.
- NCIT_C173369 hasExactSynonym "Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044" @default.
- NCIT_C173369 hasExactSynonym "DuoBody-CD3x5T4" @default.
- NCIT_C173369 hasExactSynonym "GEN 1044" @default.
- NCIT_C173369 hasExactSynonym "GEN-1044" @default.
- NCIT_C173369 hasExactSynonym "GEN1044" @default.
- NCIT_C173369 inSubset NCIT_C116977 @default.
- NCIT_C173369 inSubset NCIT_C116978 @default.
- NCIT_C173369 inSubset NCIT_C128784 @default.
- NCIT_C173369 inSubset NCIT_C157711 @default.
- NCIT_C173369 inSubset NCIT_C157712 @default.
- NCIT_C173369 inSubset NCIT_C176424 @default.
- NCIT_C173369 inSubset NCIT_C177537 @default.
- NCIT_C173369 type Class @default.
- NCIT_C173369 isDefinedBy ncit.owl @default.
- NCIT_C173369 label "Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044" @default.
- NCIT_C173369 subClassOf NCIT_C112883 @default.
- NCIT_C173369 subClassOf NCIT_C129821 @default.
- NCIT_C173369 subClassOf NCIT_C129822 @default.
- NCIT_C173369 subClassOf NCIT_C1454 @default.
- NCIT_C173369 subClassOf NCIT_C173369 @default.
- NCIT_C173369 subClassOf NCIT_C1908 @default.
- NCIT_C173369 subClassOf NCIT_C1909 @default.
- NCIT_C173369 subClassOf NCIT_C201282 @default.
- NCIT_C173369 subClassOf NCIT_C20401 @default.
- NCIT_C173369 subClassOf NCIT_C274 @default.
- NCIT_C173369 subClassOf NCIT_C28227 @default.
- NCIT_C173369 subClassOf NCIT_C307 @default.
- NCIT_C173369 subClassOf NCIT_C308 @default.