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- NCIT_C173377 IAO_0000115 "The disodium salt form of dazostinag, an agonist of the stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon intravenous administration, dazostinag targets and binds to STING and activates the STING pathway in immune cells in the tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the TME, plays a key role in the activation of the innate immune system." @default.
- NCIT_C173377 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173377 NCIT_A6 NCIT_C199200 @default.
- NCIT_C173377 NCIT_A7 NCIT_C101588 @default.
- NCIT_C173377 NCIT_NHC0 "C173377" @default.
- NCIT_C173377 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173377 NCIT_P107 "Dazostinag Disodium" @default.
- NCIT_C173377 NCIT_P108 "Dazostinag Disodium" @default.
- NCIT_C173377 NCIT_P208 "CL1407199" @default.
- NCIT_C173377 NCIT_P210 "2553413-93-5" @default.
- NCIT_C173377 NCIT_P319 "GQ7GWR7ISX" @default.
- NCIT_C173377 NCIT_P322 "CTRP" @default.
- NCIT_C173377 NCIT_P322 "FDA" @default.
- NCIT_C173377 NCIT_P322 "GDC" @default.
- NCIT_C173377 NCIT_P329 "801843" @default.
- NCIT_C173377 NCIT_P330 "801843" @default.
- NCIT_C173377 NCIT_P375 "STING Agonist TAK-676" @default.
- NCIT_C173377 NCIT_P399 "801843" @default.
- NCIT_C173377 normalizedInformationContent "100" @default.
- NCIT_C173377 referenceCount "1" @default.
- NCIT_C173377 hasExactSynonym "DAZOSTINAG DISODIUM" @default.
- NCIT_C173377 hasExactSynonym "Dazostinag Disodium" @default.
- NCIT_C173377 hasExactSynonym "STING Agonist TAK-676" @default.
- NCIT_C173377 hasExactSynonym "TAK 676" @default.
- NCIT_C173377 hasExactSynonym "TAK-676" @default.
- NCIT_C173377 hasExactSynonym "TAK676" @default.
- NCIT_C173377 inSubset NCIT_C116977 @default.
- NCIT_C173377 inSubset NCIT_C116978 @default.
- NCIT_C173377 inSubset NCIT_C128784 @default.
- NCIT_C173377 inSubset NCIT_C157711 @default.
- NCIT_C173377 inSubset NCIT_C157712 @default.
- NCIT_C173377 inSubset NCIT_C176424 @default.
- NCIT_C173377 inSubset NCIT_C177537 @default.
- NCIT_C173377 inSubset NCIT_C63923 @default.
- NCIT_C173377 type Class @default.
- NCIT_C173377 isDefinedBy ncit.owl @default.
- NCIT_C173377 label "Dazostinag Disodium" @default.
- NCIT_C173377 subClassOf NCIT_C129820 @default.
- NCIT_C173377 subClassOf NCIT_C173377 @default.
- NCIT_C173377 subClassOf NCIT_C176586 @default.
- NCIT_C173377 subClassOf NCIT_C1908 @default.
- NCIT_C173377 subClassOf NCIT_C1909 @default.
- NCIT_C173377 subClassOf NCIT_C274 @default.
- NCIT_C173377 subClassOf NCIT_C308 @default.