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- NCIT_C173413 IAO_0000115 "A prodrug of DNV3681, a small molecule quinolonyl-oxazolidinone antibiotic with activity against Gram-positive bacteria, including Clostridioides difficile. Upon intravenous administration, DNV3837 crosses the gastrointestinal barrier to reach the C. difficile infection site. The active drug DNV3681 may affect four bacterial targets including DNA-gyrase, topoisomerase IV, protein synthesis and aminoacyl-t-RNA synthetases, which leads to bacterial cell death. DNV3681 does not have antibacterial activity against aerobic and anaerobic Gram-negative bacteria, sparing intestinal Bacteroides spp. that provide colonization resistance in the digestive tract." @default.
- NCIT_C173413 NCIT_NHC0 "C173413" @default.
- NCIT_C173413 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173413 NCIT_P107 "Quinolonyl-oxazolidinone Antibiotic DNV3837" @default.
- NCIT_C173413 NCIT_P108 "Quinolonyl-oxazolidinone Antibiotic DNV3837" @default.
- NCIT_C173413 NCIT_P208 "CL1407230" @default.
- NCIT_C173413 NCIT_P210 "790704-50-6" @default.
- NCIT_C173413 NCIT_P319 "1221R21ZRQ" @default.
- NCIT_C173413 NCIT_P322 "CTRP" @default.
- NCIT_C173413 NCIT_P322 "FDA" @default.
- NCIT_C173413 NCIT_P329 "802214" @default.
- NCIT_C173413 NCIT_P330 "802214" @default.
- NCIT_C173413 NCIT_P399 "802214" @default.
- NCIT_C173413 normalizedInformationContent "100" @default.
- NCIT_C173413 referenceCount "1" @default.
- NCIT_C173413 hasExactSynonym "DNV 3837" @default.
- NCIT_C173413 hasExactSynonym "DNV-3837" @default.
- NCIT_C173413 hasExactSynonym "DNV3837" @default.
- NCIT_C173413 hasExactSynonym "MCB 3837" @default.
- NCIT_C173413 hasExactSynonym "MCB-3837" @default.
- NCIT_C173413 hasExactSynonym "MCB3837" @default.
- NCIT_C173413 hasExactSynonym "Quinolonyl-oxazolidinone Antibiotic DNV3837" @default.
- NCIT_C173413 inSubset NCIT_C116977 @default.
- NCIT_C173413 inSubset NCIT_C116978 @default.
- NCIT_C173413 inSubset NCIT_C176424 @default.
- NCIT_C173413 inSubset NCIT_C63923 @default.
- NCIT_C173413 type Class @default.
- NCIT_C173413 isDefinedBy ncit.owl @default.
- NCIT_C173413 label "Quinolonyl-oxazolidinone Antibiotic DNV3837" @default.
- NCIT_C173413 subClassOf NCIT_C173413 @default.
- NCIT_C173413 subClassOf NCIT_C1908 @default.
- NCIT_C173413 subClassOf NCIT_C1909 @default.
- NCIT_C173413 subClassOf NCIT_C254 @default.
- NCIT_C173413 subClassOf NCIT_C258 @default.