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- NCIT_C173415 IAO_0000115 "A fourth-generation, orally bioavailable, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor TQB3804 binds to and inhibits the activity of mutant forms of EGFR, including the C797S EGFR mutant, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. TQB3804 inhibits mutated forms of EGFR including C797S, which prevents covalent bond formation with third-generation EGFR inhibitor osimertinib leading to drug resistance. TQB3804 may have enhanced anti-tumor effects in tumors with C797S-mediated resistance when compared to other EGFR tyrosine kinase inhibitors." @default.
- NCIT_C173415 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173415 NCIT_NHC0 "C173415" @default.
- NCIT_C173415 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173415 NCIT_P108 "EGFR Mutant-selective Inhibitor TQB3804" @default.
- NCIT_C173415 NCIT_P208 "CL1407432" @default.
- NCIT_C173415 NCIT_P322 "GDC" @default.
- NCIT_C173415 NCIT_P329 "801857" @default.
- NCIT_C173415 NCIT_P330 "801857" @default.
- NCIT_C173415 NCIT_P375 "EGFR Mutant-selective Inhibitor TQB3804" @default.
- NCIT_C173415 NCIT_P399 "801857" @default.
- NCIT_C173415 normalizedInformationContent "100" @default.
- NCIT_C173415 referenceCount "1" @default.
- NCIT_C173415 hasExactSynonym "EGFR Mutant-selective Inhibitor TQB3804" @default.
- NCIT_C173415 hasExactSynonym "Epidermal Growth Factor Receptor Inhibitor TQB3804" @default.
- NCIT_C173415 hasExactSynonym "TQB 3804" @default.
- NCIT_C173415 hasExactSynonym "TQB-3804" @default.
- NCIT_C173415 hasExactSynonym "TQB3804" @default.
- NCIT_C173415 inSubset NCIT_C128784 @default.
- NCIT_C173415 inSubset NCIT_C157711 @default.
- NCIT_C173415 inSubset NCIT_C157712 @default.
- NCIT_C173415 inSubset NCIT_C176424 @default.
- NCIT_C173415 inSubset NCIT_C177537 @default.
- NCIT_C173415 type Class @default.
- NCIT_C173415 isDefinedBy ncit.owl @default.
- NCIT_C173415 label "EGFR Mutant-selective Inhibitor TQB3804" @default.
- NCIT_C173415 subClassOf NCIT_C129824 @default.
- NCIT_C173415 subClassOf NCIT_C129825 @default.
- NCIT_C173415 subClassOf NCIT_C1404 @default.
- NCIT_C173415 subClassOf NCIT_C163758 @default.
- NCIT_C173415 subClassOf NCIT_C163952 @default.
- NCIT_C173415 subClassOf NCIT_C173415 @default.
- NCIT_C173415 subClassOf NCIT_C1908 @default.
- NCIT_C173415 subClassOf NCIT_C1909 @default.
- NCIT_C173415 subClassOf NCIT_C1967 @default.
- NCIT_C173415 subClassOf NCIT_C2167 @default.
- NCIT_C173415 subClassOf NCIT_C2189 @default.
- NCIT_C173415 subClassOf NCIT_C274 @default.
- NCIT_C173415 subClassOf NCIT_C471 @default.