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- NCIT_C173421 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of a monoclonal antibody directed against human cell surface antigen CD47 conjugated to an as of yet not fully elucidated toxin, with potential antineoplastic activity. Upon administration of SGN-CD47M, the anti-CD47 monoclonal antibody moiety targets and binds to CD47 on tumor cell surfaces; upon internalization, the toxin moiety kills tumor cells through a mechanism of action that has not been elucidated. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed on the surface of a variety of cancer cells." @default.
- NCIT_C173421 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173421 NCIT_A7 NCIT_C25795 @default.
- NCIT_C173421 NCIT_NHC0 "C173421" @default.
- NCIT_C173421 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173421 NCIT_P107 "Anti-CD47 ADC SGN-CD47M" @default.
- NCIT_C173421 NCIT_P108 "Anti-CD47 ADC SGN-CD47M" @default.
- NCIT_C173421 NCIT_P208 "CL1407430" @default.
- NCIT_C173421 NCIT_P322 "CTRP" @default.
- NCIT_C173421 NCIT_P322 "GDC" @default.
- NCIT_C173421 NCIT_P329 "801749" @default.
- NCIT_C173421 NCIT_P330 "801749" @default.
- NCIT_C173421 NCIT_P375 "Anti-CD47 ADC SGN-CD47M" @default.
- NCIT_C173421 NCIT_P399 "801749" @default.
- NCIT_C173421 normalizedInformationContent "100" @default.
- NCIT_C173421 referenceCount "1" @default.
- NCIT_C173421 hasExactSynonym "ADC SGN-CD47M" @default.
- NCIT_C173421 hasExactSynonym "Anti-CD47 ADC SGN-CD47M" @default.
- NCIT_C173421 hasExactSynonym "Anti-CD47 Antibody-drug Conjugate SGN-CD47M" @default.
- NCIT_C173421 hasExactSynonym "SGN CD47M" @default.
- NCIT_C173421 hasExactSynonym "SGN-CD47M" @default.
- NCIT_C173421 hasExactSynonym "SGNCD47M" @default.
- NCIT_C173421 inSubset NCIT_C116977 @default.
- NCIT_C173421 inSubset NCIT_C116978 @default.
- NCIT_C173421 inSubset NCIT_C128784 @default.
- NCIT_C173421 inSubset NCIT_C157711 @default.
- NCIT_C173421 inSubset NCIT_C157712 @default.
- NCIT_C173421 inSubset NCIT_C176424 @default.
- NCIT_C173421 inSubset NCIT_C177537 @default.
- NCIT_C173421 type Class @default.
- NCIT_C173421 isDefinedBy ncit.owl @default.
- NCIT_C173421 label "Anti-CD47 ADC SGN-CD47M" @default.
- NCIT_C173421 subClassOf NCIT_C129821 @default.
- NCIT_C173421 subClassOf NCIT_C129823 @default.
- NCIT_C173421 subClassOf NCIT_C1512 @default.
- NCIT_C173421 subClassOf NCIT_C163758 @default.
- NCIT_C173421 subClassOf NCIT_C173421 @default.
- NCIT_C173421 subClassOf NCIT_C1908 @default.
- NCIT_C173421 subClassOf NCIT_C1909 @default.
- NCIT_C173421 subClassOf NCIT_C192655 @default.
- NCIT_C173421 subClassOf NCIT_C274 @default.
- NCIT_C173421 subClassOf NCIT_C307 @default.
- NCIT_C173421 subClassOf NCIT_C308 @default.