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- NCIT_C173422 IAO_0000115 "A recombinant, humanized fusion protein consisting of a cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4) single domain antibody linked to a Fc domain, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA4 antibody Fc fusion protein KN044 targets and binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.
- NCIT_C173422 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173422 NCIT_NHC0 "C173422" @default.
- NCIT_C173422 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173422 NCIT_P108 "Anti-CTLA4 Antibody Fc Fusion Protein KN044" @default.
- NCIT_C173422 NCIT_P208 "CL1407438" @default.
- NCIT_C173422 NCIT_P322 "GDC" @default.
- NCIT_C173422 NCIT_P329 "801856" @default.
- NCIT_C173422 NCIT_P330 "801856" @default.
- NCIT_C173422 NCIT_P375 "Anti-CTLA4 Antibody Fc Fusion Protein KN044" @default.
- NCIT_C173422 NCIT_P399 "801856" @default.
- NCIT_C173422 normalizedInformationContent "100" @default.
- NCIT_C173422 referenceCount "1" @default.
- NCIT_C173422 hasExactSynonym "Anti-CTLA4 Antibody Fc Fusion Protein KN044" @default.
- NCIT_C173422 hasExactSynonym "Anti-CTLA4 Antibody Fusion Protein KN044" @default.
- NCIT_C173422 hasExactSynonym "KN 044" @default.
- NCIT_C173422 hasExactSynonym "KN-044" @default.
- NCIT_C173422 hasExactSynonym "KN044" @default.
- NCIT_C173422 inSubset NCIT_C128784 @default.
- NCIT_C173422 inSubset NCIT_C157711 @default.
- NCIT_C173422 inSubset NCIT_C157712 @default.
- NCIT_C173422 inSubset NCIT_C176424 @default.
- NCIT_C173422 inSubset NCIT_C177537 @default.
- NCIT_C173422 type Class @default.
- NCIT_C173422 isDefinedBy ncit.owl @default.
- NCIT_C173422 label "Anti-CTLA4 Antibody Fc Fusion Protein KN044" @default.
- NCIT_C173422 subClassOf NCIT_C129821 @default.
- NCIT_C173422 subClassOf NCIT_C141144 @default.
- NCIT_C173422 subClassOf NCIT_C143250 @default.
- NCIT_C173422 subClassOf NCIT_C163758 @default.
- NCIT_C173422 subClassOf NCIT_C173422 @default.
- NCIT_C173422 subClassOf NCIT_C1908 @default.
- NCIT_C173422 subClassOf NCIT_C1909 @default.
- NCIT_C173422 subClassOf NCIT_C191738 @default.
- NCIT_C173422 subClassOf NCIT_C274 @default.
- NCIT_C173422 subClassOf NCIT_C307 @default.
- NCIT_C173422 subClassOf NCIT_C308 @default.