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- NCIT_C173436 IAO_0000115 "An orally available inhibitor of the epidermal growth factor receptor (EGFR), the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET) and vascular endothelial growth factor receptor (VEGFR), with potential anti-angiogenic and antineoplastic activities. Upon oral administration of HA121-28, this agent targets, binds to and inhibits the activity of EGFR, RET and VEGFR. This prevents EGFR-, RET- and VEGFR-mediated signaling, and may lead to the induction of apoptosis and inhibition of tumor growth in EGFR-, RET- and VEGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Dysregulation of RET activity plays a key role in the development and progression of a variety of cancers. Expression of VEGFR is upregulated in a variety of tumor cell types; it plays a key role in the migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death." @default.
- NCIT_C173436 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173436 NCIT_NHC0 "C173436" @default.
- NCIT_C173436 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173436 NCIT_P108 "EGFR/VEGFR/RET Inhibitor HA121-28" @default.
- NCIT_C173436 NCIT_P208 "CL1407411" @default.
- NCIT_C173436 NCIT_P322 "GDC" @default.
- NCIT_C173436 NCIT_P329 "801763" @default.
- NCIT_C173436 NCIT_P330 "801763" @default.
- NCIT_C173436 NCIT_P375 "EGFR/VEGFR/RET Inhibitor HA121-28" @default.
- NCIT_C173436 NCIT_P399 "801763" @default.
- NCIT_C173436 normalizedInformationContent "100" @default.
- NCIT_C173436 referenceCount "1" @default.
- NCIT_C173436 hasExactSynonym "EGFR/VEGFR/RET Inhibitor HA121-28" @default.
- NCIT_C173436 hasExactSynonym "HA 121-28" @default.
- NCIT_C173436 hasExactSynonym "HA-121 28" @default.
- NCIT_C173436 hasExactSynonym "HA121-28" @default.
- NCIT_C173436 inSubset NCIT_C128784 @default.
- NCIT_C173436 inSubset NCIT_C157711 @default.
- NCIT_C173436 inSubset NCIT_C157712 @default.
- NCIT_C173436 inSubset NCIT_C176424 @default.
- NCIT_C173436 inSubset NCIT_C177537 @default.
- NCIT_C173436 type Class @default.
- NCIT_C173436 isDefinedBy ncit.owl @default.
- NCIT_C173436 label "EGFR/VEGFR/RET Inhibitor HA121-28" @default.
- NCIT_C173436 subClassOf NCIT_C129824 @default.
- NCIT_C173436 subClassOf NCIT_C129825 @default.
- NCIT_C173436 subClassOf NCIT_C1404 @default.
- NCIT_C173436 subClassOf NCIT_C159438 @default.
- NCIT_C173436 subClassOf NCIT_C163758 @default.
- NCIT_C173436 subClassOf NCIT_C163952 @default.
- NCIT_C173436 subClassOf NCIT_C163953 @default.
- NCIT_C173436 subClassOf NCIT_C173436 @default.
- NCIT_C173436 subClassOf NCIT_C1742 @default.
- NCIT_C173436 subClassOf NCIT_C1908 @default.
- NCIT_C173436 subClassOf NCIT_C1909 @default.
- NCIT_C173436 subClassOf NCIT_C1967 @default.
- NCIT_C173436 subClassOf NCIT_C2167 @default.
- NCIT_C173436 subClassOf NCIT_C2189 @default.
- NCIT_C173436 subClassOf NCIT_C274 @default.
- NCIT_C173436 subClassOf NCIT_C471 @default.
- NCIT_C173436 subClassOf NCIT_C93259 @default.