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- NCIT_C173536 IAO_0000115 "An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, Bcl-2 inhibitor LP-108 targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival." @default.
- NCIT_C173536 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173536 NCIT_NHC0 "C173536" @default.
- NCIT_C173536 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173536 NCIT_P108 "Bcl-2 Inhibitor LP-108" @default.
- NCIT_C173536 NCIT_P208 "CL1407495" @default.
- NCIT_C173536 NCIT_P322 "GDC" @default.
- NCIT_C173536 NCIT_P329 "801885" @default.
- NCIT_C173536 NCIT_P330 "801885" @default.
- NCIT_C173536 NCIT_P375 "Bcl-2 Inhibitor LP-108" @default.
- NCIT_C173536 NCIT_P399 "801885" @default.
- NCIT_C173536 normalizedInformationContent "100" @default.
- NCIT_C173536 referenceCount "1" @default.
- NCIT_C173536 hasExactSynonym "Bcl-2 Inhibitor LP-108" @default.
- NCIT_C173536 hasExactSynonym "LP 108" @default.
- NCIT_C173536 hasExactSynonym "LP-108" @default.
- NCIT_C173536 hasExactSynonym "LP108" @default.
- NCIT_C173536 inSubset NCIT_C128784 @default.
- NCIT_C173536 inSubset NCIT_C157711 @default.
- NCIT_C173536 inSubset NCIT_C157712 @default.
- NCIT_C173536 inSubset NCIT_C176424 @default.
- NCIT_C173536 inSubset NCIT_C177537 @default.
- NCIT_C173536 type Class @default.
- NCIT_C173536 isDefinedBy ncit.owl @default.
- NCIT_C173536 label "Bcl-2 Inhibitor LP-108" @default.
- NCIT_C173536 subClassOf NCIT_C129839 @default.
- NCIT_C173536 subClassOf NCIT_C159200 @default.
- NCIT_C173536 subClassOf NCIT_C163758 @default.
- NCIT_C173536 subClassOf NCIT_C173536 @default.
- NCIT_C173536 subClassOf NCIT_C1908 @default.
- NCIT_C173536 subClassOf NCIT_C1909 @default.
- NCIT_C173536 subClassOf NCIT_C192025 @default.
- NCIT_C173536 subClassOf NCIT_C274 @default.