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- NCIT_C173539 IAO_0000115 "A bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279; Programmed Death 1) and lymphocyte activation gene 3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, tobemstomig targets and binds to both PD-1 and LAG-3 expressed on T-cells and inhibits the PD-1- and LAG-3-mediated downregulation of T-cell activation and proliferation. This may lead to cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 play key roles in suppressing T-cell activation and proliferation." @default.
- NCIT_C173539 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173539 NCIT_NHC0 "C173539" @default.
- NCIT_C173539 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173539 NCIT_P107 "Tobemstomig" @default.
- NCIT_C173539 NCIT_P108 "Tobemstomig" @default.
- NCIT_C173539 NCIT_P208 "CL1407490" @default.
- NCIT_C173539 NCIT_P210 "2648839-43-2" @default.
- NCIT_C173539 NCIT_P319 "93NRF4S9HR" @default.
- NCIT_C173539 NCIT_P322 "CTRP" @default.
- NCIT_C173539 NCIT_P322 "FDA" @default.
- NCIT_C173539 NCIT_P322 "GDC" @default.
- NCIT_C173539 NCIT_P329 "801886" @default.
- NCIT_C173539 NCIT_P330 "801886" @default.
- NCIT_C173539 NCIT_P375 "Anti-PD-1/Anti-LAG-3 Bispecific Antibody RO7247669" @default.
- NCIT_C173539 NCIT_P399 "801886" @default.
- NCIT_C173539 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173539 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173539 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173539 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173539 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173539 normalizedInformationContent "100" @default.
- NCIT_C173539 referenceCount "1" @default.
- NCIT_C173539 hasExactSynonym "Anti-PD-1/Anti-LAG-3 Bispecific Antibody RO7247669" @default.
- NCIT_C173539 hasExactSynonym "Anti-PD1/Anti-LAG3 Bispecific Antibody RO7247669" @default.
- NCIT_C173539 hasExactSynonym "RO 7247669" @default.
- NCIT_C173539 hasExactSynonym "RO-7247669" @default.
- NCIT_C173539 hasExactSynonym "RO7247669" @default.
- NCIT_C173539 hasExactSynonym "TOBEMSTOMIG" @default.
- NCIT_C173539 hasExactSynonym "Tobemstomig" @default.
- NCIT_C173539 inSubset NCIT_C116977 @default.
- NCIT_C173539 inSubset NCIT_C116978 @default.
- NCIT_C173539 inSubset NCIT_C128784 @default.
- NCIT_C173539 inSubset NCIT_C157711 @default.
- NCIT_C173539 inSubset NCIT_C157712 @default.
- NCIT_C173539 inSubset NCIT_C176424 @default.
- NCIT_C173539 inSubset NCIT_C177537 @default.
- NCIT_C173539 inSubset NCIT_C63923 @default.
- NCIT_C173539 type Class @default.
- NCIT_C173539 isDefinedBy ncit.owl @default.
- NCIT_C173539 label "Tobemstomig" @default.
- NCIT_C173539 subClassOf NCIT_C124946 @default.
- NCIT_C173539 subClassOf NCIT_C128037 @default.
- NCIT_C173539 subClassOf NCIT_C129821 @default.
- NCIT_C173539 subClassOf NCIT_C129822 @default.
- NCIT_C173539 subClassOf NCIT_C134305 @default.
- NCIT_C173539 subClassOf NCIT_C141144 @default.
- NCIT_C173539 subClassOf NCIT_C143250 @default.
- NCIT_C173539 subClassOf NCIT_C1454 @default.
- NCIT_C173539 subClassOf NCIT_C163758 @default.
- NCIT_C173539 subClassOf NCIT_C173539 @default.
- NCIT_C173539 subClassOf NCIT_C1908 @default.
- NCIT_C173539 subClassOf NCIT_C1909 @default.
- NCIT_C173539 subClassOf NCIT_C200483 @default.
- NCIT_C173539 subClassOf NCIT_C20401 @default.
- NCIT_C173539 subClassOf NCIT_C274 @default.
- NCIT_C173539 subClassOf NCIT_C28227 @default.
- NCIT_C173539 subClassOf NCIT_C307 @default.
- NCIT_C173539 subClassOf NCIT_C308 @default.