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- NCIT_C173540 IAO_0000115 "A recombinant human heavy chain only antibody (HCAb) directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, porustobart targets and binds to CTLA-4 expressed on T-cells, and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. In addition, porustobart induces an antibody-dependent cell cytotoxicity (ADCC). CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system. Porustobart, being a HCAb, is smaller than conventional antibodies which may allow for increased tissue penetration." @default.
- NCIT_C173540 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173540 NCIT_A7 NCIT_C17489 @default.
- NCIT_C173540 NCIT_NHC0 "C173540" @default.
- NCIT_C173540 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173540 NCIT_P107 "Porustobart" @default.
- NCIT_C173540 NCIT_P108 "Porustobart" @default.
- NCIT_C173540 NCIT_P208 "CL1407491" @default.
- NCIT_C173540 NCIT_P210 "2649372-91-6" @default.
- NCIT_C173540 NCIT_P319 "JJY4JHN685" @default.
- NCIT_C173540 NCIT_P322 "CTRP" @default.
- NCIT_C173540 NCIT_P322 "FDA" @default.
- NCIT_C173540 NCIT_P322 "GDC" @default.
- NCIT_C173540 NCIT_P329 "801868" @default.
- NCIT_C173540 NCIT_P330 "801868" @default.
- NCIT_C173540 NCIT_P375 "Anti-CTLA-4 Monoclonal Antibody HBM4003" @default.
- NCIT_C173540 NCIT_P399 "801868" @default.
- NCIT_C173540 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173540 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173540 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173540 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173540 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173540 normalizedInformationContent "100" @default.
- NCIT_C173540 referenceCount "1" @default.
- NCIT_C173540 hasExactSynonym "Anti-CTLA-4 Monoclonal Antibody HBM4003" @default.
- NCIT_C173540 hasExactSynonym "Anti-CTLA4 Monoclonal Antibody HBM4003" @default.
- NCIT_C173540 hasExactSynonym "HBM 4003" @default.
- NCIT_C173540 hasExactSynonym "HBM-4003" @default.
- NCIT_C173540 hasExactSynonym "HBM4003" @default.
- NCIT_C173540 hasExactSynonym "PORUSTOBART" @default.
- NCIT_C173540 hasExactSynonym "Porustobart" @default.
- NCIT_C173540 inSubset NCIT_C116977 @default.
- NCIT_C173540 inSubset NCIT_C116978 @default.
- NCIT_C173540 inSubset NCIT_C128784 @default.
- NCIT_C173540 inSubset NCIT_C157711 @default.
- NCIT_C173540 inSubset NCIT_C157712 @default.
- NCIT_C173540 inSubset NCIT_C176424 @default.
- NCIT_C173540 inSubset NCIT_C177537 @default.
- NCIT_C173540 inSubset NCIT_C63923 @default.
- NCIT_C173540 type Class @default.
- NCIT_C173540 isDefinedBy ncit.owl @default.
- NCIT_C173540 label "Porustobart" @default.
- NCIT_C173540 subClassOf NCIT_C128036 @default.
- NCIT_C173540 subClassOf NCIT_C129821 @default.
- NCIT_C173540 subClassOf NCIT_C129822 @default.
- NCIT_C173540 subClassOf NCIT_C141144 @default.
- NCIT_C173540 subClassOf NCIT_C143250 @default.
- NCIT_C173540 subClassOf NCIT_C163758 @default.
- NCIT_C173540 subClassOf NCIT_C173540 @default.
- NCIT_C173540 subClassOf NCIT_C1908 @default.
- NCIT_C173540 subClassOf NCIT_C1909 @default.
- NCIT_C173540 subClassOf NCIT_C191738 @default.
- NCIT_C173540 subClassOf NCIT_C20401 @default.
- NCIT_C173540 subClassOf NCIT_C274 @default.
- NCIT_C173540 subClassOf NCIT_C307 @default.
- NCIT_C173540 subClassOf NCIT_C308 @default.