Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C173541> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- NCIT_C173541 IAO_0000115 "A tetravalent bispecific antibody targeting both the pro-apoptotic death receptor tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAILR2; death receptor 5; DR5) and cadherin-17 (CDH17), with potential pro-apoptotic and antineoplastic activities. Upon administration of anti-TRAILR2/CDH17 tetravalent bispecific antibody BI 905711, the antibody targets and binds to both TRAILR2 and CDH17, expressed on tumor cells. Receptor clustering and activation of TRAILR2 induces apoptosis in CDH17-positive cancer cells. Activation of TRAILR2 plays a key role in the induction of apoptosis. CDH17-dependent clustering of TRAILR2 allows BI 905711 to selectively induce apoptosis in CDH17-expressing tumor cells thereby increasing efficacy and decreasing liver toxicity. CDH17 is overexpressed in a variety of cancer cell types while its expression is restricted in normal liver tissue." @default.
- NCIT_C173541 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173541 NCIT_A7 NCIT_C143098 @default.
- NCIT_C173541 NCIT_A7 NCIT_C18178 @default.
- NCIT_C173541 NCIT_NHC0 "C173541" @default.
- NCIT_C173541 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173541 NCIT_P107 "Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711" @default.
- NCIT_C173541 NCIT_P108 "Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711" @default.
- NCIT_C173541 NCIT_P208 "CL1407500" @default.
- NCIT_C173541 NCIT_P322 "CTRP" @default.
- NCIT_C173541 NCIT_P322 "GDC" @default.
- NCIT_C173541 NCIT_P329 "801873" @default.
- NCIT_C173541 NCIT_P330 "801873" @default.
- NCIT_C173541 NCIT_P375 "Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711" @default.
- NCIT_C173541 NCIT_P399 "801873" @default.
- NCIT_C173541 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173541 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173541 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173541 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173541 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173541 normalizedInformationContent "100" @default.
- NCIT_C173541 referenceCount "1" @default.
- NCIT_C173541 hasExactSynonym "Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711" @default.
- NCIT_C173541 hasExactSynonym "BI 905711" @default.
- NCIT_C173541 hasExactSynonym "BI-905711" @default.
- NCIT_C173541 hasExactSynonym "BI905711" @default.
- NCIT_C173541 hasExactSynonym "Bi-specific Agent BI 905711" @default.
- NCIT_C173541 hasExactSynonym "CDH17-targeting TRAILR2 Agonist BI 905711" @default.
- NCIT_C173541 inSubset NCIT_C116977 @default.
- NCIT_C173541 inSubset NCIT_C116978 @default.
- NCIT_C173541 inSubset NCIT_C128784 @default.
- NCIT_C173541 inSubset NCIT_C157711 @default.
- NCIT_C173541 inSubset NCIT_C157712 @default.
- NCIT_C173541 inSubset NCIT_C176424 @default.
- NCIT_C173541 inSubset NCIT_C177537 @default.
- NCIT_C173541 type Class @default.
- NCIT_C173541 isDefinedBy ncit.owl @default.
- NCIT_C173541 label "Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711" @default.
- NCIT_C173541 subClassOf NCIT_C129821 @default.
- NCIT_C173541 subClassOf NCIT_C129822 @default.
- NCIT_C173541 subClassOf NCIT_C1454 @default.
- NCIT_C173541 subClassOf NCIT_C173541 @default.
- NCIT_C173541 subClassOf NCIT_C1908 @default.
- NCIT_C173541 subClassOf NCIT_C1909 @default.
- NCIT_C173541 subClassOf NCIT_C20401 @default.
- NCIT_C173541 subClassOf NCIT_C274 @default.
- NCIT_C173541 subClassOf NCIT_C28227 @default.
- NCIT_C173541 subClassOf NCIT_C307 @default.
- NCIT_C173541 subClassOf NCIT_C308 @default.