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- NCIT_C173548 IAO_0000115 "A humanized agonistic immunoglobulin G4 (IgG4) monoclonal antibody targeting the costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, evunzekibart targets and binds to CD137 expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells, and CD137 is activated upon crosslinking to Fc-gamma receptors (FcgRs) on macrophages. This enhances CD137-mediated signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes a CTL-mediated anti-tumor immune response as well as induces NK-mediated tumor cell killing and suppresses the immunosuppressive activity of T-regulatory cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. 4-1BB and FcgRs are both highly expressed in the tumor environment (TME) while their co-expression in non-tumor tissues is low. This may prevent systemic adverse effects." @default.
- NCIT_C173548 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173548 NCIT_NHC0 "C173548" @default.
- NCIT_C173548 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173548 NCIT_P108 "Evunzekibart" @default.
- NCIT_C173548 NCIT_P208 "CL1407499" @default.
- NCIT_C173548 NCIT_P210 "2639688-77-8" @default.
- NCIT_C173548 NCIT_P319 "AKZ8CT8FMF" @default.
- NCIT_C173548 NCIT_P322 "FDA" @default.
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- NCIT_C173548 NCIT_P329 "801898" @default.
- NCIT_C173548 NCIT_P330 "801898" @default.
- NCIT_C173548 NCIT_P375 "Anti-CD137 Agonistic Monoclonal Antibody ATOR-1017" @default.
- NCIT_C173548 NCIT_P399 "801898" @default.
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- NCIT_C173548 normalizedInformationContent "100" @default.
- NCIT_C173548 referenceCount "1" @default.
- NCIT_C173548 hasExactSynonym "ATOR 1017" @default.
- NCIT_C173548 hasExactSynonym "ATOR-1017" @default.
- NCIT_C173548 hasExactSynonym "ATOR1017" @default.
- NCIT_C173548 hasExactSynonym "Anti-4-1BB Monoclonal Antibody ATOR-1017" @default.
- NCIT_C173548 hasExactSynonym "Anti-CD137 Agonist Monoclonal Antibody ATOR-1017" @default.
- NCIT_C173548 hasExactSynonym "Anti-CD137 Agonistic Monoclonal Antibody ATOR-1017" @default.
- NCIT_C173548 hasExactSynonym "Anti-CD137 Monoclonal Antibody ATOR-1017" @default.
- NCIT_C173548 hasExactSynonym "EVUNZEKIBART" @default.
- NCIT_C173548 hasExactSynonym "Evunzekibart" @default.
- NCIT_C173548 inSubset NCIT_C128784 @default.
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- NCIT_C173548 type Class @default.
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- NCIT_C173548 label "Evunzekibart" @default.
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