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- NCIT_C173598 IAO_0000115 "A monoclonal antibody directed against latent human transforming growth factor (TGF)-beta 1 (TGFb1; TGF-b1), with potential antineoplastic activity. Upon administration, linavonkibart specifically targets, binds to, and inhibits the activation of latent TGFb1 complexes, thereby preventing TGFb1-mediated signaling. This abrogates TGFb1-mediated immunosuppression, enhances anti-tumor immunity in the tumor microenvironment (TME) and promotes a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells leading to tumor cell death. This may lead to a reduction in TGFb1-dependent proliferation of cancer cells. The TGF-beta signaling pathway is often deregulated in tumors and plays a key role in the regulation of cell growth, differentiation, apoptosis, motility, invasion, and angiogenesis. It plays a key role in immunosuppression in the TME. TGFb1 is the predominant isoform in many tumors." @default.
- NCIT_C173598 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173598 NCIT_A7 NCIT_C20457 @default.
- NCIT_C173598 NCIT_NHC0 "C173598" @default.
- NCIT_C173598 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173598 NCIT_P107 "Linavonkibart" @default.
- NCIT_C173598 NCIT_P108 "Linavonkibart" @default.
- NCIT_C173598 NCIT_P208 "CL1407357" @default.
- NCIT_C173598 NCIT_P210 "2640981-30-0" @default.
- NCIT_C173598 NCIT_P319 "8SSL98OST3" @default.
- NCIT_C173598 NCIT_P322 "CTRP" @default.
- NCIT_C173598 NCIT_P322 "FDA" @default.
- NCIT_C173598 NCIT_P322 "GDC" @default.
- NCIT_C173598 NCIT_P329 "802238" @default.
- NCIT_C173598 NCIT_P330 "802238" @default.
- NCIT_C173598 NCIT_P375 "Anti-latent TGF-beta 1 Monoclonal Antibody SRK-181" @default.
- NCIT_C173598 NCIT_P399 "802238" @default.
- NCIT_C173598 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173598 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173598 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173598 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173598 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173598 normalizedInformationContent "100" @default.
- NCIT_C173598 referenceCount "1" @default.
- NCIT_C173598 hasExactSynonym "Anti-TGF-beta 1 Monoclonal Antibody SRK-181" @default.
- NCIT_C173598 hasExactSynonym "Anti-latent TGF-b1 Monoclonal Antibody SRK-181" @default.
- NCIT_C173598 hasExactSynonym "Anti-latent TGF-beta 1 Monoclonal Antibody SRK-181" @default.
- NCIT_C173598 hasExactSynonym "Anti-latent TGFb1 Monoclonal Antibody SRK-181" @default.
- NCIT_C173598 hasExactSynonym "LINAVONKIBART" @default.
- NCIT_C173598 hasExactSynonym "Linavonkibart" @default.
- NCIT_C173598 hasExactSynonym "SRK 181" @default.
- NCIT_C173598 hasExactSynonym "SRK-181" @default.
- NCIT_C173598 hasExactSynonym "SRK181" @default.
- NCIT_C173598 hasExactSynonym "SRT-BETA-1-AB3" @default.
- NCIT_C173598 inSubset NCIT_C116977 @default.
- NCIT_C173598 inSubset NCIT_C116978 @default.
- NCIT_C173598 inSubset NCIT_C128784 @default.
- NCIT_C173598 inSubset NCIT_C157711 @default.
- NCIT_C173598 inSubset NCIT_C157712 @default.
- NCIT_C173598 inSubset NCIT_C176424 @default.
- NCIT_C173598 inSubset NCIT_C177537 @default.
- NCIT_C173598 inSubset NCIT_C63923 @default.
- NCIT_C173598 type Class @default.
- NCIT_C173598 isDefinedBy ncit.owl @default.
- NCIT_C173598 label "Linavonkibart" @default.
- NCIT_C173598 subClassOf NCIT_C129821 @default.
- NCIT_C173598 subClassOf NCIT_C129822 @default.
- NCIT_C173598 subClassOf NCIT_C173598 @default.
- NCIT_C173598 subClassOf NCIT_C1908 @default.
- NCIT_C173598 subClassOf NCIT_C1909 @default.
- NCIT_C173598 subClassOf NCIT_C20401 @default.
- NCIT_C173598 subClassOf NCIT_C274 @default.
- NCIT_C173598 subClassOf NCIT_C307 @default.
- NCIT_C173598 subClassOf NCIT_C308 @default.