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- NCIT_C173633 IAO_0000115 "An orally available inhibitor of both monomer and dimer forms of activating mutations of the serine/threonine-protein kinase BRAF (B-raf) protein, including V600 BRAF mutations, non-V600 BRAF mutations, and RAF fusions, with potential antineoplastic activity. Upon administration, BRAF inhibitor BGB-3245 targets and binds to both monomeric and dimeric forms of activating BRAF mutations and fusions. This may result in the inhibition of BRAF-mediated signaling and inhibit proliferation in tumor cells expressing BRAF mutations and fusions. BRAF belongs to the RAF family of serine/threonine protein kinases and plays a role in regulating the mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumor cell proliferation and survival. BRAF mutations and fusions have been identified in a number of solid tumors and are drivers of cancer growth." @default.
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- NCIT_C173633 NCIT_NHC0 "C173633" @default.
- NCIT_C173633 NCIT_P106 "Organic Chemical" @default.
- NCIT_C173633 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173633 NCIT_P107 "BRAF Inhibitor BGB-3245" @default.
- NCIT_C173633 NCIT_P108 "BRAF Inhibitor BGB-3245" @default.
- NCIT_C173633 NCIT_P208 "CL1407365" @default.
- NCIT_C173633 NCIT_P322 "CTRP" @default.
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- NCIT_C173633 NCIT_P329 "802245" @default.
- NCIT_C173633 NCIT_P330 "802245" @default.
- NCIT_C173633 NCIT_P375 "BRAF Inhibitor BGB-3245" @default.
- NCIT_C173633 NCIT_P399 "802245" @default.
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- NCIT_C173633 normalizedInformationContent "100" @default.
- NCIT_C173633 referenceCount "1" @default.
- NCIT_C173633 hasExactSynonym "BGB 3245" @default.
- NCIT_C173633 hasExactSynonym "BGB-3245" @default.
- NCIT_C173633 hasExactSynonym "BGB3245" @default.
- NCIT_C173633 hasExactSynonym "BRAF Inhibitor BGB-3245" @default.
- NCIT_C173633 hasExactSynonym "BRAF Monomer/Dimer Inhibitor BGB-3245" @default.
- NCIT_C173633 inSubset NCIT_C116977 @default.
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- NCIT_C173633 type Class @default.
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- NCIT_C173633 label "BRAF Inhibitor BGB-3245" @default.
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- NCIT_C173633 subClassOf NCIT_C61074 @default.