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- NCIT_C173640 IAO_0000115 "A recombinant adenoviral serotype 5 (Ad5) in which the Ad5-based vector fiber is replaced by the fiber from the human B adenovirus serotype 35 (F35), encoding for the human guanylyl cyclase C (hGCC), and fused to the synthetic Pan DR epitope (PADRE), with potential antineoplastic and immunomodulating activities. Upon intramuscular administration of the Ad5/F35-hGCC-PADRE, the Ad5/F35 targets CD46, which is expressed widely on most tumor cells, and the virus is taken up by cells. Once inside the cells, the virus expresses hGCC. The expressed hGCC induces both humoral and cellular immune responses against tumor cells expressing the hGCC antigen. This results in the immune-mediated killing of tumor cells. The hGCC protein is normally restricted to intestinal epithelial cells but is overexpressed by metastatic colorectal tumors. PADRE is a helper T-lymphocyte epitope that is able to augment the magnitude and duration of the cytotoxic T-lymphocyte (CTL) response. The inclusion of the chimeric Ad5/F35 fiber increases viral uptake in cells through CD46." @default.
- NCIT_C173640 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173640 NCIT_A7 NCIT_C126979 @default.
- NCIT_C173640 NCIT_NHC0 "C173640" @default.
- NCIT_C173640 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173640 NCIT_P107 "Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE" @default.
- NCIT_C173640 NCIT_P108 "Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE" @default.
- NCIT_C173640 NCIT_P208 "CL1407372" @default.
- NCIT_C173640 NCIT_P322 "CTRP" @default.
- NCIT_C173640 NCIT_P322 "GDC" @default.
- NCIT_C173640 NCIT_P329 "802251" @default.
- NCIT_C173640 NCIT_P330 "802251" @default.
- NCIT_C173640 NCIT_P375 "Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE" @default.
- NCIT_C173640 NCIT_P399 "802251" @default.
- NCIT_C173640 normalizedInformationContent "100" @default.
- NCIT_C173640 referenceCount "1" @default.
- NCIT_C173640 hasExactSynonym "Ad5.F35-hGCC-PADRE" @default.
- NCIT_C173640 hasExactSynonym "Ad5/F35-hGCC-PADRE" @default.
- NCIT_C173640 hasExactSynonym "Adenovirus 5/F35-HGCC-PADRE" @default.
- NCIT_C173640 hasExactSynonym "Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE" @default.
- NCIT_C173640 inSubset NCIT_C116977 @default.
- NCIT_C173640 inSubset NCIT_C116978 @default.
- NCIT_C173640 inSubset NCIT_C128784 @default.
- NCIT_C173640 inSubset NCIT_C157711 @default.
- NCIT_C173640 inSubset NCIT_C157712 @default.
- NCIT_C173640 inSubset NCIT_C176424 @default.
- NCIT_C173640 inSubset NCIT_C177537 @default.
- NCIT_C173640 type Class @default.
- NCIT_C173640 isDefinedBy ncit.owl @default.
- NCIT_C173640 label "Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE" @default.
- NCIT_C173640 subClassOf NCIT_C129820 @default.
- NCIT_C173640 subClassOf NCIT_C173640 @default.
- NCIT_C173640 subClassOf NCIT_C1908 @default.
- NCIT_C173640 subClassOf NCIT_C1909 @default.
- NCIT_C173640 subClassOf NCIT_C1962 @default.
- NCIT_C173640 subClassOf NCIT_C274 @default.
- NCIT_C173640 subClassOf NCIT_C307 @default.
- NCIT_C173640 subClassOf NCIT_C308 @default.
- NCIT_C173640 subClassOf NCIT_C61199 @default.