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- NCIT_C173645 IAO_0000115 "A tri-specific T-cell engager and monoclonal antibody targeting CD38, a human cell surface glycoprotein and tumor-associated antigen (TAA), CD3, a T-cell surface antigen, and CD28, a T-cell specific surface glycoprotein and co-stimulatory molecule, with potential antineoplastic activity. Upon intravenous administration, anti-CD38/CD3/CD28 tri-specific monoclonal antibody SAR442257 targets and binds to CD3 and CD28 on T-cells and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. In addition, SAR442257 can also directly target CD28 expressed on tumor cells, such as multiple myeloma cells, thereby enhancing the anti-tumor activity of this agent and allowing it to bind to tumor cells when CD38 is occupied by other antibodies. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis." @default.
- NCIT_C173645 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173645 NCIT_A7 NCIT_C84323 @default.
- NCIT_C173645 NCIT_NHC0 "C173645" @default.
- NCIT_C173645 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173645 NCIT_P107 "Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257" @default.
- NCIT_C173645 NCIT_P108 "Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257" @default.
- NCIT_C173645 NCIT_P208 "CL1407369" @default.
- NCIT_C173645 NCIT_P322 "CTRP" @default.
- NCIT_C173645 NCIT_P322 "GDC" @default.
- NCIT_C173645 NCIT_P329 "802010" @default.
- NCIT_C173645 NCIT_P330 "802010" @default.
- NCIT_C173645 NCIT_P375 "Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257" @default.
- NCIT_C173645 NCIT_P399 "802010" @default.
- NCIT_C173645 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173645 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173645 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173645 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173645 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173645 normalizedInformationContent "100" @default.
- NCIT_C173645 referenceCount "1" @default.
- NCIT_C173645 hasExactSynonym "Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257" @default.
- NCIT_C173645 hasExactSynonym "SAR 442257" @default.
- NCIT_C173645 hasExactSynonym "SAR-442257" @default.
- NCIT_C173645 hasExactSynonym "SAR442257" @default.
- NCIT_C173645 hasExactSynonym "Tri-specific T-cell Engager SAR442257" @default.
- NCIT_C173645 inSubset NCIT_C116977 @default.
- NCIT_C173645 inSubset NCIT_C116978 @default.
- NCIT_C173645 inSubset NCIT_C128784 @default.
- NCIT_C173645 inSubset NCIT_C157711 @default.
- NCIT_C173645 inSubset NCIT_C157712 @default.
- NCIT_C173645 inSubset NCIT_C176424 @default.
- NCIT_C173645 inSubset NCIT_C177537 @default.
- NCIT_C173645 type Class @default.
- NCIT_C173645 isDefinedBy ncit.owl @default.
- NCIT_C173645 label "Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257" @default.
- NCIT_C173645 subClassOf NCIT_C129821 @default.
- NCIT_C173645 subClassOf NCIT_C129822 @default.
- NCIT_C173645 subClassOf NCIT_C155321 @default.
- NCIT_C173645 subClassOf NCIT_C163758 @default.
- NCIT_C173645 subClassOf NCIT_C164008 @default.
- NCIT_C173645 subClassOf NCIT_C173645 @default.
- NCIT_C173645 subClassOf NCIT_C1908 @default.
- NCIT_C173645 subClassOf NCIT_C1909 @default.
- NCIT_C173645 subClassOf NCIT_C20401 @default.
- NCIT_C173645 subClassOf NCIT_C274 @default.
- NCIT_C173645 subClassOf NCIT_C307 @default.
- NCIT_C173645 subClassOf NCIT_C308 @default.