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- NCIT_C173713 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR T-lymphocytes TAK-102 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation." @default.
- NCIT_C173713 NCIT_NHC0 "C173713" @default.
- NCIT_C173713 NCIT_P106 "Cell" @default.
- NCIT_C173713 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173713 NCIT_P108 "Anti-GPC3-CAR T-lymphocytes TAK-102" @default.
- NCIT_C173713 NCIT_P208 "CL1407565" @default.
- NCIT_C173713 NCIT_P329 "801936" @default.
- NCIT_C173713 NCIT_P330 "801936" @default.
- NCIT_C173713 NCIT_P366 "Anti-CEA_IgCD28TCR-Transduced_Autologous_T_Cells" @default.
- NCIT_C173713 NCIT_P399 "801936" @default.
- NCIT_C173713 normalizedInformationContent "100" @default.
- NCIT_C173713 referenceCount "1" @default.
- NCIT_C173713 hasExactSynonym "Anti-GPC3 CAR T Cells TAK-102" @default.
- NCIT_C173713 hasExactSynonym "Anti-GPC3-CAR T-lymphocytes TAK-102" @default.
- NCIT_C173713 hasExactSynonym "CAR T Cells TAK-102" @default.
- NCIT_C173713 hasExactSynonym "Glypican-3-specific CAR T Cells TAK-102" @default.
- NCIT_C173713 hasExactSynonym "TAK 102" @default.
- NCIT_C173713 hasExactSynonym "TAK-102" @default.
- NCIT_C173713 hasExactSynonym "TAK102" @default.
- NCIT_C173713 inSubset NCIT_C128784 @default.
- NCIT_C173713 inSubset NCIT_C176424 @default.
- NCIT_C173713 type Class @default.
- NCIT_C173713 isDefinedBy ncit.owl @default.
- NCIT_C173713 label "Anti-GPC3-CAR T-lymphocytes TAK-102" @default.
- NCIT_C173713 subClassOf NCIT_C129820 @default.
- NCIT_C173713 subClassOf NCIT_C129821 @default.
- NCIT_C173713 subClassOf NCIT_C129826 @default.
- NCIT_C173713 subClassOf NCIT_C137999 @default.
- NCIT_C173713 subClassOf NCIT_C142078 @default.
- NCIT_C173713 subClassOf NCIT_C154231 @default.
- NCIT_C173713 subClassOf NCIT_C173713 @default.
- NCIT_C173713 subClassOf NCIT_C1908 @default.
- NCIT_C173713 subClassOf NCIT_C1909 @default.
- NCIT_C173713 subClassOf NCIT_C1962 @default.
- NCIT_C173713 subClassOf NCIT_C274 @default.
- NCIT_C173713 subClassOf NCIT_C307 @default.
- NCIT_C173713 subClassOf NCIT_C308 @default.