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- NCIT_C173724 IAO_0000115 "A recombinant humanized monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-claudin18.2 monoclonal antibody AB011 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C173724 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173724 NCIT_A7 NCIT_C150412 @default.
- NCIT_C173724 NCIT_NHC0 "C173724" @default.
- NCIT_C173724 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173724 NCIT_P108 "Anti-claudin18.2 Monoclonal Antibody AB011" @default.
- NCIT_C173724 NCIT_P208 "CL1407568" @default.
- NCIT_C173724 NCIT_P322 "GDC" @default.
- NCIT_C173724 NCIT_P329 "802013" @default.
- NCIT_C173724 NCIT_P330 "802013" @default.
- NCIT_C173724 NCIT_P375 "Anti-claudin18.2 Monoclonal Antibody AB011" @default.
- NCIT_C173724 NCIT_P399 "802013" @default.
- NCIT_C173724 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173724 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173724 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173724 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173724 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173724 normalizedInformationContent "100" @default.
- NCIT_C173724 referenceCount "1" @default.
- NCIT_C173724 hasExactSynonym "AB 011" @default.
- NCIT_C173724 hasExactSynonym "AB-011" @default.
- NCIT_C173724 hasExactSynonym "AB011" @default.
- NCIT_C173724 hasExactSynonym "Anti-CLDN18.2 Monoclonal Antibody AB011" @default.
- NCIT_C173724 hasExactSynonym "Anti-claudin18.2 Monoclonal Antibody AB011" @default.
- NCIT_C173724 inSubset NCIT_C128784 @default.
- NCIT_C173724 inSubset NCIT_C157711 @default.
- NCIT_C173724 inSubset NCIT_C157712 @default.
- NCIT_C173724 inSubset NCIT_C176424 @default.
- NCIT_C173724 inSubset NCIT_C177537 @default.
- NCIT_C173724 type Class @default.
- NCIT_C173724 isDefinedBy ncit.owl @default.
- NCIT_C173724 label "Anti-claudin18.2 Monoclonal Antibody AB011" @default.
- NCIT_C173724 subClassOf NCIT_C129821 @default.
- NCIT_C173724 subClassOf NCIT_C129822 @default.
- NCIT_C173724 subClassOf NCIT_C163758 @default.
- NCIT_C173724 subClassOf NCIT_C173724 @default.
- NCIT_C173724 subClassOf NCIT_C179676 @default.
- NCIT_C173724 subClassOf NCIT_C1908 @default.
- NCIT_C173724 subClassOf NCIT_C1909 @default.
- NCIT_C173724 subClassOf NCIT_C200250 @default.
- NCIT_C173724 subClassOf NCIT_C20401 @default.
- NCIT_C173724 subClassOf NCIT_C274 @default.
- NCIT_C173724 subClassOf NCIT_C307 @default.
- NCIT_C173724 subClassOf NCIT_C308 @default.