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- NCIT_C173725 IAO_0000115 "An antisense oligonucleotide (ASO) targeting the interferon regulatory factor 4 (IRF4) mRNA, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, frenlosirsen hybridizes with IRF4 mRNA, which blocks translation of the IRF4 protein. Reduction of IRF4 levels prevents the expression of IRF4-controlled tumor promoter genes, and may enhance tumor cell apoptosis and prevent T-cell exhaustion. IRF4, a transcription factor expressed in lymphocytes and essential for plasma cell differentiation, is involved in immune cell development and plays a key role in T-cell functions. It is overexpressed in certain tumor cell types and is a key regulator of multiple genes controlling tumor cell survival." @default.
- NCIT_C173725 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173725 NCIT_NHC0 "C173725" @default.
- NCIT_C173725 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C173725 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173725 NCIT_P107 "Frenlosirsen" @default.
- NCIT_C173725 NCIT_P108 "Frenlosirsen" @default.
- NCIT_C173725 NCIT_P208 "CL1407569" @default.
- NCIT_C173725 NCIT_P210 "2304711-81-5" @default.
- NCIT_C173725 NCIT_P319 "J2Y9QT3BWL" @default.
- NCIT_C173725 NCIT_P322 "CTRP" @default.
- NCIT_C173725 NCIT_P322 "FDA" @default.
- NCIT_C173725 NCIT_P322 "GDC" @default.
- NCIT_C173725 NCIT_P329 "802018" @default.
- NCIT_C173725 NCIT_P330 "802018" @default.
- NCIT_C173725 NCIT_P375 "Anti-IRF4 Antisense Oligonucleotide ION251" @default.
- NCIT_C173725 NCIT_P399 "802018" @default.
- NCIT_C173725 normalizedInformationContent "100" @default.
- NCIT_C173725 referenceCount "1" @default.
- NCIT_C173725 hasExactSynonym "Anti-IRF4 ASO ION251" @default.
- NCIT_C173725 hasExactSynonym "Anti-IRF4 ASO IONIS-IRF4-2.5Rx" @default.
- NCIT_C173725 hasExactSynonym "Anti-IRF4 Antisense Oligonucleotide ION251" @default.
- NCIT_C173725 hasExactSynonym "FRENLOSIRSEN" @default.
- NCIT_C173725 hasExactSynonym "Frenlosirsen" @default.
- NCIT_C173725 hasExactSynonym "ION 251" @default.
- NCIT_C173725 hasExactSynonym "ION-251" @default.
- NCIT_C173725 hasExactSynonym "ION251" @default.
- NCIT_C173725 hasExactSynonym "IONIS-IRF4-2.5Rx" @default.
- NCIT_C173725 hasExactSynonym "ON-935918" @default.
- NCIT_C173725 inSubset NCIT_C116977 @default.
- NCIT_C173725 inSubset NCIT_C116978 @default.
- NCIT_C173725 inSubset NCIT_C128784 @default.
- NCIT_C173725 inSubset NCIT_C157711 @default.
- NCIT_C173725 inSubset NCIT_C157712 @default.
- NCIT_C173725 inSubset NCIT_C176424 @default.
- NCIT_C173725 inSubset NCIT_C177537 @default.
- NCIT_C173725 inSubset NCIT_C63923 @default.
- NCIT_C173725 type Class @default.
- NCIT_C173725 isDefinedBy ncit.owl @default.
- NCIT_C173725 label "Frenlosirsen" @default.
- NCIT_C173725 subClassOf NCIT_C1291 @default.
- NCIT_C173725 subClassOf NCIT_C173725 @default.
- NCIT_C173725 subClassOf NCIT_C1908 @default.
- NCIT_C173725 subClassOf NCIT_C1909 @default.
- NCIT_C173725 subClassOf NCIT_C1962 @default.
- NCIT_C173725 subClassOf NCIT_C307 @default.